| Position | Starters | Team | Games | Opponents |
| C | Will Smith | LAD | 6 | Mia(3) @Atl(3) |
| 1B | Spencer Torkelson | Det | 7 | @Hou(3) @LAA(4) |
| 2B | Bryson Stott | Phi | 6 | Was(3) Ari(3) |
| SS | Mookie Betts | LAD | 6 | Mia(3) @Atl(3) |
| 3B | Connor Norby | Mia | 6 | @LAD(3) Oak(3) |
| OF | Andy Pages | LAD | 6 | Mia(3) @Atl(3) |
| OF | Mike Trout | LAA | 6 | @Sea(2) Det(4) |
| OF | Steven Kwan | Cle | 7 | Min(4) @Tor(3) |
| DH (SS) | Trea Turner | Phi | 6 | Was(3) Ari(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Agustin Ramirez | Mia | 6 | @LAD(3) Oak(3) |
| 1B | Christian Walker | Hou | 6 | Det(3) @ChA(3) |
| 2B (OF) | Jose Altuve | Hou | 6 | Det(3) @ChA(3) |
| SS | Geraldo Perdomo | Ari | 6 | @NYN(3) @Phi(3) |
| 3B | Ke'Bryan Hayes | Pit | 6 | ChN(3) SD(3) |
| OF | Alek Thomas | Ari | 6 | @NYN(3) @Phi(3) |
| DH (3B) | Ryan McMahon | Col | 7 | Atl(3) @SF(4) |
| Position | 2nd Backup | Team | Games | Opponents |
| C | Ryan Jeffers | Min | 7 | @Cle(4) @Bos(3) |
| 3B (SS,OF) | Jose Caballero | TB | 6 | KC(3) @NYA(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Jose Berrios | Tor | 6 | Bos(3) Cle(3) | Last Pitched Thursday May 1st |
| 2nd SP | Andrew Heaney | Pit | 6 | ChN(3) SD(3) | This Sunday vs SD (Stephen Kolek) |
| 3rd SP | Zac Gallen | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Thursday May 1st |
| 4th SP | Tyler Glasnow | LAD | 6 | Mia(3) @Atl(3) | Last Pitched Sunday April 27th |
| 5th SP | Aaron Nola | Phi | 6 | Was(3) Ari(3) | Last Pitched Saturday May 3rd |
| 6th SP | Seth Lugo | KC | 6 | @TB(3) @Bal(3) | Last Pitched Thursday May 1st |
| 7th SP | David Peterson | NYN | 8 | @Was(1) Ari(3) @StL(4) | Last Pitched Tuesday April 29th |
| 8th SP | Germán Márquez | Col | 7 | Atl(3) @SF(4) | This Sunday at SF (Logan Webb) |
| 9th SP | Jameson Taillon | ChN | 6 | @Pit(3) @Mil(3) | Last Pitched Saturday May 3rd |
| 10th SP | Kris Bubic | KC | 6 | @TB(3) @Bal(3) | Last Pitched Saturday May 3rd |
| 1st RP | José Alvarado | Phi | 6 | Was(3) Ari(3) | Last Pitched Friday May 2nd |
| 2nd RP | Tanner Scott | LAD | 6 | Mia(3) @Atl(3) | Last Pitched Friday May 2nd |
| 3rd RP | Robert Suarez | SD | 5 | SF(2) @Pit(3) | Last Pitched Saturday May 3rd |
| Position | Injured List | Team | Games | Opponents |
| DH | Jake Cronenworth | SD | 5 | SF(2) @Pit(3) |
| OF | Parker Meadows | Det | 7 | @Hou(3) @LAA(4) |
| OF | Tyler O'Neill | Bal | 6 | NYA(3) KC(3) |