| Position | Starters | Team | Games | Opponents |
| C | Jonah Heim | Tex | 7 | Oak(4) Sea(3) |
| 1B | Tyler Soderstrom | Oak | 7 | @Tex(4) @Mia(3) |
| 2B | Matt McLain | Cin | 8 | StL(5) Was(3) |
| SS | Anthony Volpe | NYA | 6 | @Bal(3) TB(3) |
| 3B | Jordan Westburg | Bal | 6 | NYA(3) KC(3) |
| OF | Corbin Carroll | Ari | 6 | @NYN(3) @Phi(3) |
| OF | Jung Hoo Lee | SF | 6 | @SD(2) Col(4) |
| OF | Riley Greene | Det | 7 | @Hou(3) @LAA(4) |
| DH (OF) | Andrew McCutchen | Pit | 6 | ChN(3) SD(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Alejandro Kirk | Tor | 6 | Bos(3) Cle(3) |
| 1B | Michael Toglia | Col | 7 | Atl(3) @SF(4) |
| 2B (SS,OF) | Kyren Paris | LAA | 6 | @Sea(2) Det(4) |
| SS | Jeremy Pena | Hou | 6 | Det(3) @ChA(3) |
| 3B | Josh Jung | Tex | 7 | Oak(4) Sea(3) |
| OF | Spencer Steer | Cin | 8 | StL(5) Was(3) |
| DH (OF) | Jordan Walker | StL | 9 | @Cin(5) NYN(4) |
| Position | 2nd Backup | Team | Games | Opponents |
| 2B | Brendan Rodgers | Hou | 6 | Det(3) @ChA(3) |
| DH (1B) | Triston Casas | Bos | 6 | @Tor(3) Min(3) |
| Position | Bench | Team | Games | Opponents |
| OF | Jackson Merrill | SD | 5 | SF(2) @Pit(3) |
| Pitching Staff Alignment |
| 5 Starts, 3 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Spencer Schwellenbach | Atl | 6 | @Col(3) LAD(3) | Last Pitched Saturday May 3rd |
| 2nd SP | Bryan Woo | Sea | 5 | LAA(2) @Tex(3) | Last Pitched Friday May 2nd |
| 3rd SP | Tylor Megill | NYN | 8 | @Was(1) Ari(3) @StL(4) | This Sunday at StL (Andre Pallante) |
| 4th SP | Robbie Ray | SF | 6 | @SD(2) Col(4) | Last Pitched Friday May 2nd |
| 5th SP | Landen Roupp | SF | 6 | @SD(2) Col(4) | Last Pitched Wednesday April 30th |
| 6th SP | Jack Leiter | Tex | 7 | Oak(4) Sea(3) | Last Pitched Friday May 2nd |
| 7th SP | Logan Allen | Cle | 7 | Min(4) @Tor(3) | Last Pitched Friday May 2nd |
| 8th SP | Max Scherzer | Tor | 6 | Bos(3) Cle(3) | Last Pitched Saturday March 29th |
| 1st RP | Mason Miller | Oak | 7 | @Tex(4) @Mia(3) | Last Pitched Saturday May 3rd |
| 2nd RP | Carlos Estevez | KC | 6 | @TB(3) @Bal(3) | Last Pitched Wednesday April 30th |
| 3rd RP | Ryan Walker | SF | 6 | @SD(2) Col(4) | Last Pitched Saturday May 3rd |
| 4th RP | Cade Smith | Cle | 7 | Min(4) @Tor(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Games | Opponents |
| SP | George Kirby | Sea | 5 | LAA(2) @Tex(3) |
| SP | Grayson Rodriguez | Bal | 6 | NYA(3) KC(3) |
| SP | Richard Fitts | Bos | 6 | @Tor(3) Min(3) |