| Position | Starters | Team | Games | Opponents |
| C | Dillon Dingler | Det | 7 | @Hou(3) @LAA(4) |
| 1B | Vladimir Guerrero Jr. | Tor | 6 | Bos(3) Cle(3) |
| 2B | Wilmer Flores | SF | 6 | @SD(2) Col(4) |
| SS | Willy Adames | SF | 6 | @SD(2) Col(4) |
| 3B | Rafael Devers | Bos | 6 | @Tor(3) Min(3) |
| OF | Jordan Beck | Col | 7 | Atl(3) @SF(4) |
| OF | Yordan Alvarez | Hou | 6 | Det(3) @ChA(3) |
| OF | Juan Soto | NYN | 8 | @Was(1) Ari(3) @StL(4) |
| DH (1B) | Ryan O'Hearn | Bal | 6 | NYA(3) KC(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Gabriel Moreno | Ari | 6 | @NYN(3) @Phi(3) |
| 1B | Nolan Schanuel | LAA | 6 | @Sea(2) Det(4) |
| 2B | Nico Hoerner | ChN | 6 | @Pit(3) @Mil(3) |
| SS | J.P. Crawford | Sea | 5 | LAA(2) @Tex(3) |
| 3B (2B) | Dylan Moore | Sea | 5 | LAA(2) @Tex(3) |
| OF | Christopher Morel | TB | 6 | KC(3) @NYA(3) |
| DH (2B) | Brandon Lowe | TB | 6 | KC(3) @NYA(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Hunter Greene | Cin | 8 | StL(5) Was(3) | Last Pitched Friday May 2nd |
| 2nd SP | Max Fried | NYA | 6 | @Bal(3) TB(3) | Last Pitched Friday May 2nd |
| 3rd SP | Framber Valdez | Hou | 6 | Det(3) @ChA(3) | Last Pitched Friday May 2nd |
| 4th SP | Logan Webb | SF | 6 | @SD(2) Col(4) | This Sunday vs Col (Germán Márquez) |
| 5th SP | Jose Quintana | Mil | 6 | @ChA(3) ChN(3) | Last Pitched Saturday May 3rd |
| 6th SP | Matt Boyd | ChN | 6 | @Pit(3) @Mil(3) | Last Pitched Wednesday April 30th |
| 7th SP | Hunter Dobbins | Bos | 6 | @Tor(3) Min(3) | Last Pitched Saturday May 3rd |
| 8th SP | JP Sears | Oak | 7 | @Tex(4) @Mia(3) | This Sunday at Mia (Edward Cabrera) |
| 9th SP | Ronel Blanco | Hou | 6 | Det(3) @ChA(3) | Last Pitched Monday April 28th |
| 10th SP | Spencer Strider | Atl | 6 | @Col(3) LAD(3) | Last Pitched Wednesday April 16th |
| 11th SP | Bubba Chandler | Pit | 6 | ChN(3) SD(3) | Has Not Played Yet |
| 12th SP | Ryan Gusto | Hou | 6 | Det(3) @ChA(3) | Last Pitched Tuesday April 29th |
| 1st RP | Kyle Finnegan | Was | 7 | NYN(1) @Phi(3) @Cin(3) | Last Pitched Thursday May 1st |
| 2nd RP | Raisel Iglesias | Atl | 6 | @Col(3) LAD(3) | Last Pitched Saturday May 3rd |
| 3rd RP | Jhoan Duran | Min | 7 | @Cle(4) @Bos(3) | Last Pitched Saturday May 3rd |
| Position | Injured List | Team | Games | Opponents |
| C | Ivan Herrera | StL | 9 | @Cin(5) NYN(4) |
| OF | Ronald Acuna Jr. | Atl | 6 | @Col(3) LAD(3) |