| Position | Starters | Team | Games | Opponents |
| C | William Contreras | Mil | 6 | @ChA(3) ChN(3) |
| 1B | Bryce Harper | Phi | 6 | Was(3) Ari(3) |
| 2B (SS) | Brendan Donovan | StL | 9 | @Cin(5) NYN(4) |
| SS | Bobby Witt Jr. | KC | 6 | @TB(3) @Bal(3) |
| 3B | Alex Bregman | Bos | 6 | @Tor(3) Min(3) |
| OF | Kyle Tucker | ChN | 6 | @Pit(3) @Mil(3) |
| OF | Randy Arozarena | Sea | 5 | LAA(2) @Tex(3) |
| OF | Brent Rooker | Oak | 7 | @Tex(4) @Mia(3) |
| DH (OF) | Jarren Duran | Bos | 6 | @Tor(3) Min(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Logan O'Hoppe | LAA | 6 | @Sea(2) Det(4) |
| 1B | Ryan Mountcastle | Bal | 6 | NYA(3) KC(3) |
| 2B | Andrés Gimenez | Tor | 6 | Bos(3) Cle(3) |
| SS | Xander Bogaerts | SD | 5 | SF(2) @Pit(3) |
| 3B | Nolan Arenado | StL | 9 | @Cin(5) NYN(4) |
| OF | Trent Grisham | NYA | 6 | @Bal(3) TB(3) |
| DH (OF) | Lourdes Gurriel | Ari | 6 | @NYN(3) @Phi(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| OF | JJ Bleday | Oak | 7 | @Tex(4) @Mia(3) |
| DH (3B,2B,OF) | Maikel Garcia | KC | 6 | @TB(3) @Bal(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Cole Ragans | KC | 6 | @TB(3) @Bal(3) | Last Pitched Thursday April 24th |
| 2nd SP | Brandon Pfaadt | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Saturday May 3rd |
| 3rd SP | Joe Ryan | Min | 7 | @Cle(4) @Bos(3) | Last Pitched Friday May 2nd |
| 4th SP | Carlos Rodon | NYA | 6 | @Bal(3) TB(3) | Last Pitched Tuesday April 29th |
| 5th SP | Dylan Cease | SD | 5 | SF(2) @Pit(3) | Last Pitched Friday May 2nd |
| 6th SP | Taj Bradley | TB | 6 | KC(3) @NYA(3) | This Sunday at NYA (Will Warren) |
| 7th SP | Matthew Liberatore | StL | 9 | @Cin(5) NYN(4) | Last Pitched Thursday May 1st |
| 8th SP | Michael Wacha | KC | 6 | @TB(3) @Bal(3) | Last Pitched Friday May 2nd |
| 9th SP | Jake Irvin | Was | 7 | NYN(1) @Phi(3) @Cin(3) | Last Pitched Wednesday April 30th |
| 10th SP | Eduardo Rodriguez | Ari | 6 | @NYN(3) @Phi(3) | This Sunday at Phi (Ranger Suarez) |
| 11th SP | Will Warren | NYA | 6 | @Bal(3) TB(3) | This Sunday vs TB (Taj Bradley) |
| 1st RP | Andres Munoz | Sea | 5 | LAA(2) @Tex(3) | Last Pitched Saturday May 3rd |
| 2nd RP | Jeff Hoffman | Tor | 6 | Bos(3) Cle(3) | Last Pitched Friday May 2nd |
| Position | Injured List | Team | Games | Opponents |
| SP | Brandon Woodruff | Mil | 6 | @ChA(3) ChN(3) |
| SP | Luis Gil | NYA | 6 | @Bal(3) TB(3) |
| 2B | Ketel Marte | Ari | 6 | @NYN(3) @Phi(3) |