| Position | Starters | Team | Games | Opponents |
| C | Salvador Perez | KC | 6 | @TB(3) @Bal(3) |
| 1B | Willson Contreras | StL | 9 | @Cin(5) NYN(4) |
| 2B | Luis Garcia | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| SS | CJ Abrams | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| 3B | Jorge Polanco | Sea | 5 | LAA(2) @Tex(3) |
| OF | Kerry Carpenter | Det | 7 | @Hou(3) @LAA(4) |
| OF | Nick Castellanos | Phi | 6 | Was(3) Ari(3) |
| OF | Teoscar Hernández | LAD | 6 | Mia(3) @Atl(3) |
| DH (OF) | Mike Yastrzemski | SF | 6 | @SD(2) Col(4) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Austin Wells | NYA | 6 | @Bal(3) TB(3) |
| 1B | Nathaniel Lowe | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| 2B | Luis Rengifo | LAA | 6 | @Sea(2) Det(4) |
| 3B | Alec Bohm | Phi | 6 | Was(3) Ari(3) |
| OF | Trevor Larnach | Min | 7 | @Cle(4) @Bos(3) |
| DH (OF) | Taylor Ward | LAA | 6 | @Sea(2) Det(4) |
| Position | 2nd Backup | Team | Games | Opponents |
| 1B | Jake Burger | Tex | 7 | Oak(4) Sea(3) |
| OF | Anthony Santander | Tor | 6 | Bos(3) Cle(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Paul Skenes | Pit | 6 | ChN(3) SD(3) | Last Pitched Thursday May 1st |
| 2nd SP | Tarik Skubal | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Friday May 2nd |
| 3rd SP | Zack Wheeler | Phi | 6 | Was(3) Ari(3) | Last Pitched Tuesday April 29th |
| 4th SP | Michael King | SD | 5 | SF(2) @Pit(3) | Last Pitched Wednesday April 30th |
| 5th SP | Nick Pivetta | SD | 5 | SF(2) @Pit(3) | Last Pitched Tuesday April 29th |
| 6th SP | Clay Holmes | NYN | 8 | @Was(1) Ari(3) @StL(4) | Last Pitched Friday May 2nd |
| 7th SP | Pablo Lopez | Min | 7 | @Cle(4) @Bos(3) | Last Pitched Wednesday April 30th |
| 8th SP | Hayden Wesneski | Hou | 6 | Det(3) @ChA(3) | Last Pitched Friday April 25th |
| 9th SP | Yusei Kikuchi | LAA | 6 | @Sea(2) Det(4) | Last Pitched Thursday May 1st |
| 10th SP | Ryan Pepiot | TB | 6 | KC(3) @NYA(3) | Last Pitched Friday May 2nd |
| 1st RP | Luke Jackson | Tex | 7 | Oak(4) Sea(3) | Last Pitched Wednesday April 30th |
| 2nd RP | Justin Martinez | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Wednesday April 30th |
| 3rd RP | Ryan Pressly | ChN | 6 | @Pit(3) @Mil(3) | Last Pitched Thursday May 1st |
| 4th RP | Camilo Doval | SF | 6 | @SD(2) Col(4) | Last Pitched Saturday May 3rd |
| Position | Injured List | Team | Games | Opponents |
| SP | Jared Jones | Pit | 6 | ChN(3) SD(3) |
| 1B | Luis Arraez | SD | 5 | SF(2) @Pit(3) |
| SS | Ezequiel Tovar | Col | 7 | Atl(3) @SF(4) |