| Position | Starters | Team | Games | Opponents |
| C | Will Smith | LAD | 6 | Mia(3) @Atl(3) |
| 1B | Vladimir Guerrero Jr. | Tor | 6 | Bos(3) Cle(3) |
| 2B | Ketel Marte | Ari | 6 | @NYN(3) @Phi(3) |
| SS | Jacob Wilson | Oak | 7 | @Tex(4) @Mia(3) |
| 3B | Alex Bregman | Bos | 6 | @Tor(3) Min(3) |
| OF | George Springer | Tor | 6 | Bos(3) Cle(3) |
| OF | Brent Rooker | Oak | 7 | @Tex(4) @Mia(3) |
| OF | Bryan Reynolds | Pit | 6 | ChN(3) SD(3) |
| DH | Marcell Ozuna | Atl | 6 | @Col(3) LAD(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Salvador Perez | KC | 6 | @TB(3) @Bal(3) |
| 1B | Nathaniel Lowe | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| 2B | Nick Gonzales | Pit | 6 | ChN(3) SD(3) |
| SS | Ezequiel Tovar | Col | 7 | Atl(3) @SF(4) |
| 3B (SS,OF) | Jose Caballero | TB | 6 | KC(3) @NYA(3) |
| OF | Adolis Garcia | Tex | 7 | Oak(4) Sea(3) |
| DH (OF) | Spencer Steer | Cin | 8 | StL(5) Was(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| 2B (1B) | Romy Gonzalez | Bos | 6 | @Tor(3) Min(3) |
| OF | Jordan Walker | StL | 9 | @Cin(5) NYN(4) |
| Position | 3rd Backup | Team | Games | Opponents |
| 2B | Brendan Rodgers | Hou | 6 | Det(3) @ChA(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | George Kirby | Sea | 5 | LAA(2) @Tex(3) | Has Not Played Yet |
| 2nd SP | Carlos Rodon | NYA | 6 | @Bal(3) TB(3) | Last Pitched Tuesday April 29th |
| 3rd SP | Framber Valdez | Hou | 6 | Det(3) @ChA(3) | Last Pitched Friday May 2nd |
| 4th SP | Shane Baz | TB | 6 | KC(3) @NYA(3) | Last Pitched Thursday May 1st |
| 5th SP | Tomoyuki Sugano | Bal | 6 | NYA(3) KC(3) | Last Pitched Saturday May 3rd |
| 6th SP | Merrill Kelly | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Friday May 2nd |
| 7th SP | Bowden Francis | Tor | 6 | Bos(3) Cle(3) | This Sunday vs Cle (Tanner Bibee) |
| 8th SP | Erick Fedde | StL | 9 | @Cin(5) NYN(4) | This Sunday vs NYN (Blade Tidwell) |
| 9th SP | Randy Vasquez | SD | 5 | SF(2) @Pit(3) | Last Pitched Saturday May 3rd |
| 1st RP | Kyle Finnegan | Was | 7 | NYN(1) @Phi(3) @Cin(3) | Last Pitched Thursday May 1st |
| 2nd RP | Ryan Pressly | ChN | 6 | @Pit(3) @Mil(3) | Last Pitched Thursday May 1st |
| 3rd RP | Trevor Megill | Mil | 6 | @ChA(3) ChN(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Games | Opponents |
| SP | Yu Darvish | SD | 5 | SF(2) @Pit(3) |
| 3B | Matt Vierling | Det | 7 | @Hou(3) @LAA(4) |
| SP | Reynaldo Lopez | Atl | 6 | @Col(3) LAD(3) |