| Position | Starters | Team | Games | Opponents |
| C | Agustin Ramirez | Mia | 6 | @LAD(3) Oak(3) |
| 1B | Bryce Harper | Phi | 6 | Was(3) Ari(3) |
| 2B (SS) | Gabriel Arias | Cle | 7 | Min(4) @Tor(3) |
| SS | Bo Bichette | Tor | 6 | Bos(3) Cle(3) |
| 3B | Coby Mayo | Bal | 6 | NYA(3) KC(3) |
| OF | James Wood | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| OF | Lawrence Butler | Oak | 7 | @Tex(4) @Mia(3) |
| OF | Oneil Cruz | Pit | 6 | ChN(3) SD(3) |
| DH | Shohei Ohtani | LAD | 6 | Mia(3) @Atl(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Dillon Dingler | Det | 7 | @Hou(3) @LAA(4) |
| 1B | Nick Kurtz | Oak | 7 | @Tex(4) @Mia(3) |
| 2B | Christian Moore | LAA | 6 | @Sea(2) Det(4) |
| SS | Jordan Lawlar | Ari | 6 | @NYN(3) @Phi(3) |
| 3B | Jorge Polanco | Sea | 5 | LAA(2) @Tex(3) |
| OF | Kerry Carpenter | Det | 7 | @Hou(3) @LAA(4) |
| DH (1B) | Ben Rice | NYA | 6 | @Bal(3) TB(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| 1B | Jac Caglianone | KC | 6 | @TB(3) @Bal(3) |
| 2B | Otto Lopez | Mia | 6 | @LAD(3) Oak(3) |
| 3B | Ryan McMahon | Col | 7 | Atl(3) @SF(4) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Tarik Skubal | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Friday May 2nd |
| 2nd SP | Kris Bubic | KC | 6 | @TB(3) @Bal(3) | Last Pitched Saturday May 3rd |
| 3rd SP | Drew Rasmussen | TB | 6 | KC(3) @NYA(3) | Last Pitched Wednesday April 30th |
| 4th SP | Nick Lodolo | Cin | 8 | StL(5) Was(3) | Last Pitched Saturday May 3rd |
| 5th SP | Tanner Bibee | Cle | 7 | Min(4) @Tor(3) | This Sunday at Tor (Bowden Francis) |
| 6th SP | Reese Olson | Det | 7 | @Hou(3) @LAA(4) | This Sunday at LAA (Jack Kochanowicz) |
| 7th SP | Tony Gonsolin | LAD | 6 | Mia(3) @Atl(3) | Last Pitched Wednesday April 30th |
| 8th SP | Zebby Matthews | Min | 7 | @Cle(4) @Bos(3) | Has Not Played Yet |
| 9th SP | José Soriano | LAA | 6 | @Sea(2) Det(4) | Last Pitched Friday May 2nd |
| 1st RP | Jeff Hoffman | Tor | 6 | Bos(3) Cle(3) | Last Pitched Friday May 2nd |
| 2nd RP | Emilio Pagan | Cin | 8 | StL(5) Was(3) | Last Pitched Friday May 2nd |
| 3rd RP | Ryan Walker | SF | 6 | @SD(2) Col(4) | Last Pitched Saturday May 3rd |
| Position | Injured List | Team | Games | Opponents |
| SS | Corey Seager | Tex | 7 | Oak(4) Sea(3) |
| OF | Josh Lowe | TB | 6 | KC(3) @NYA(3) |
| OF | Ronald Acuna Jr. | Atl | 6 | @Col(3) LAD(3) |