| Position | Starters | Team | Games | Opponents |
| C | Keibert Ruiz | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| 1B | Triston Casas | Bos | 6 | @Tor(3) Min(3) |
| 2B | Matt McLain | Cin | 8 | StL(5) Was(3) |
| SS | Elly De La Cruz | Cin | 8 | StL(5) Was(3) |
| 3B | Josh Jung | Tex | 7 | Oak(4) Sea(3) |
| OF | Juan Soto | NYN | 8 | @Was(1) Ari(3) @StL(4) |
| OF | Riley Greene | Det | 7 | @Hou(3) @LAA(4) |
| OF | Yordan Alvarez | Hou | 6 | Det(3) @ChA(3) |
| DH (OF) | Jordan Beck | Col | 7 | Atl(3) @SF(4) |
| Position | 1st Backup | Team | Games | Opponents |
| C | J.T. Realmuto | Phi | 6 | Was(3) Ari(3) |
| 1B | Michael Toglia | Col | 7 | Atl(3) @SF(4) |
| 2B | Bryson Stott | Phi | 6 | Was(3) Ari(3) |
| SS | Marcelo Mayer | Bos | 6 | @Tor(3) Min(3) |
| 3B | Alec Bohm | Phi | 6 | Was(3) Ari(3) |
| OF | Randy Arozarena | Sea | 5 | LAA(2) @Tex(3) |
| DH (1B) | Matt Mervis | Mia | 6 | @LAD(3) Oak(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| C | Samuel Basallo | Bal | 6 | NYA(3) KC(3) |
| 1B | Bryce Eldridge | SF | 6 | @SD(2) Col(4) |
| SS (3B,OF) | Javier Baez | Det | 7 | @Hou(3) @LAA(4) |
| 3B | Caleb Durbin | Mil | 6 | @ChA(3) ChN(3) |
| OF | Heston Kjerstad | Bal | 6 | NYA(3) KC(3) |
| Position | 3rd Backup | Team | Games | Opponents |
| SS | Sebastian Walcott | Tex | 7 | Oak(4) Sea(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Jesus Luzardo | Phi | 6 | Was(3) Ari(3) | Last Pitched Friday May 2nd |
| 2nd SP | Bryce Miller | Sea | 5 | LAA(2) @Tex(3) | Last Pitched Tuesday April 29th |
| 3rd SP | Cristopher Sanchez | Phi | 6 | Was(3) Ari(3) | Last Pitched Wednesday April 30th |
| 4th SP | Chris Sale | Atl | 6 | @Col(3) LAD(3) | Last Pitched Wednesday April 30th |
| 5th SP | MacKenzie Gore | Was | 7 | NYN(1) @Phi(3) @Cin(3) | This Sunday at Cin (Nick Martinez) |
| 6th SP | Robbie Ray | SF | 6 | @SD(2) Col(4) | Last Pitched Friday May 2nd |
| 7th SP | Jose Berrios | Tor | 6 | Bos(3) Cle(3) | Last Pitched Thursday May 1st |
| 1st RP | Carlos Estevez | KC | 6 | @TB(3) @Bal(3) | Last Pitched Wednesday April 30th |
| 2nd RP | Aroldis Chapman | Bos | 6 | @Tor(3) Min(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Games | Opponents |
| SP | Eury Perez | Mia | 6 | @LAD(3) Oak(3) |
| DH | Luke Keaschall | Min | 7 | @Cle(4) @Bos(3) |
| SP | Shane McClanahan | TB | 6 | KC(3) @NYA(3) |