| Position | Starters | Team | Games | Opponents |
| C | Shea Langeliers | Oak | 7 | @Tex(4) @Mia(3) |
| 1B | Pete Alonso | NYN | 8 | @Was(1) Ari(3) @StL(4) |
| 2B | Jose Altuve | Hou | 6 | Det(3) @ChA(3) |
| SS | Francisco Lindor | NYN | 8 | @Was(1) Ari(3) @StL(4) |
| 3B | Mark Vientos | NYN | 8 | @Was(1) Ari(3) @StL(4) |
| OF | Sal Frelick | Mil | 6 | @ChA(3) ChN(3) |
| OF | Corbin Carroll | Ari | 6 | @NYN(3) @Phi(3) |
| OF | Luis Robert Jr. | ChA | 6 | Mil(3) Hou(3) |
| DH (1B) | Michael Busch | ChN | 6 | @Pit(3) @Mil(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Tyler Heineman | Tor | 6 | Bos(3) Cle(3) |
| 1B | Ty France | Min | 7 | @Cle(4) @Bos(3) |
| 2B | Nolan Gorman | StL | 9 | @Cin(5) NYN(4) |
| SS | Xander Bogaerts | SD | 5 | SF(2) @Pit(3) |
| 3B (2B,OF) | Zach McKinstry | Det | 7 | @Hou(3) @LAA(4) |
| OF | Dylan Crews | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| DH (OF) | JJ Bleday | Oak | 7 | @Tex(4) @Mia(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| 2B (3B,OF) | Maikel Garcia | KC | 6 | @TB(3) @Bal(3) |
| OF | Jesus Sanchez | Mia | 6 | @LAD(3) Oak(3) |
| Position | Bench | Team | Games | Opponents |
| OF | Roman Anthony | Bos | 6 | @Tor(3) Min(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Zack Wheeler | Phi | 6 | Was(3) Ari(3) | Last Pitched Tuesday April 29th |
| 2nd SP | Kodai Senga | NYN | 8 | @Was(1) Ari(3) @StL(4) | Last Pitched Thursday May 1st |
| 3rd SP | Roki Sasaki | LAD | 6 | Mia(3) @Atl(3) | Last Pitched Saturday May 3rd |
| 4th SP | Tyler Mahle | Tex | 7 | Oak(4) Sea(3) | Last Pitched Thursday May 1st |
| 5th SP | Dylan Cease | SD | 5 | SF(2) @Pit(3) | Last Pitched Friday May 2nd |
| 6th SP | Zack Littell | TB | 6 | KC(3) @NYA(3) | Last Pitched Saturday May 3rd |
| 7th SP | Zach Eflin | Bal | 6 | NYA(3) KC(3) | Last Pitched Monday April 7th |
| 1st RP | Luke Weaver | NYA | 6 | @Bal(3) TB(3) | Last Pitched Friday May 2nd |
| 2nd RP | Pete Fairbanks | TB | 6 | KC(3) @NYA(3) | Last Pitched Saturday May 3rd |
| 3rd RP | Raisel Iglesias | Atl | 6 | @Col(3) LAD(3) | Last Pitched Saturday May 3rd |
| 4th RP | Devin Williams | NYA | 6 | @Bal(3) TB(3) | Last Pitched Friday May 2nd |
| 5th RP | Tommy Kahnle | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Thursday May 1st |
| Position | Injured List | Team | Games | Opponents |
| SP | Brandon Woodruff | Mil | 6 | @ChA(3) ChN(3) |
| SP | Max Scherzer | Tor | 6 | Bos(3) Cle(3) |
| SP | Shane Bieber | Cle | 7 | Min(4) @Tor(3) |