| Position | Starters | Team | Games | Opponents |
| C | Logan O'Hoppe | LAA | 6 | @Sea(2) Det(4) |
| 1B (OF) | Pavin Smith | Ari | 6 | @NYN(3) @Phi(3) |
| 2B (OF) | Tim Tawa | Ari | 6 | @NYN(3) @Phi(3) |
| SS | Anthony Volpe | NYA | 6 | @Bal(3) TB(3) |
| 3B | Austin Riley | Atl | 6 | @Col(3) LAD(3) |
| OF | Cedric Mullins II | Bal | 6 | NYA(3) KC(3) |
| OF | Byron Buxton | Min | 7 | @Cle(4) @Bos(3) |
| OF | TJ Friedl | Cin | 8 | StL(5) Was(3) |
| DH (1B) | Jonathan Aranda | TB | 6 | KC(3) @NYA(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Joey Bart | Pit | 6 | ChN(3) SD(3) |
| 1B | Paul Goldschmidt | NYA | 6 | @Bal(3) TB(3) |
| 2B (3B,OF) | Jonathan India | KC | 6 | @TB(3) @Bal(3) |
| 3B | Connor Norby | Mia | 6 | @LAD(3) Oak(3) |
| OF | Heliot Ramos | SF | 6 | @SD(2) Col(4) |
| DH (OF) | Kyle Stowers | Mia | 6 | @LAD(3) Oak(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| 1B (OF) | Luke Raley | Sea | 5 | LAA(2) @Tex(3) |
| DH (1B) | Yandy Diaz | TB | 6 | KC(3) @NYA(3) |
| Position | Bench | Team | Games | Opponents |
| 3B | Matt Shaw | ChN | 6 | @Pit(3) @Mil(3) |
| OF | Evan Carter | Tex | 7 | Oak(4) Sea(3) |
| OF | Tyler O'Neill | Bal | 6 | NYA(3) KC(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Taj Bradley | TB | 6 | KC(3) @NYA(3) | This Sunday at NYA (Will Warren) |
| 2nd SP | Hunter Brown | Hou | 6 | Det(3) @ChA(3) | Last Pitched Saturday May 3rd |
| 3rd SP | Corbin Burnes | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Wednesday April 30th |
| 4th SP | Bryan Woo | Sea | 5 | LAA(2) @Tex(3) | Last Pitched Friday May 2nd |
| 5th SP | Max Meyer | Mia | 6 | @LAD(3) Oak(3) | Last Pitched Saturday May 3rd |
| 6th SP | Matthew Liberatore | StL | 9 | @Cin(5) NYN(4) | Last Pitched Thursday May 1st |
| 7th SP | Tanner Houck | Bos | 6 | @Tor(3) Min(3) | Last Pitched Thursday May 1st |
| 8th SP | Chase Dollander | Col | 7 | Atl(3) @SF(4) | Last Pitched Wednesday April 30th |
| 1st RP | Edwin Diaz | NYN | 8 | @Was(1) Ari(3) @StL(4) | Last Pitched Saturday April 26th |
| 2nd RP | Kenley Jansen | LAA | 6 | @Sea(2) Det(4) | Last Pitched Saturday May 3rd |
| 3rd RP | Tanner Scott | LAD | 6 | Mia(3) @Atl(3) | Last Pitched Friday May 2nd |
| Position | Injured List | Team | Games | Opponents |
| 2B | Jake Cronenworth | SD | 5 | SF(2) @Pit(3) |
| SP | Blake Snell | LAD | 6 | Mia(3) @Atl(3) |
| 1B | Christian Encarnacion-Strand | Cin | 8 | StL(5) Was(3) |