| Position | Starters | Team | Games | Opponents |
| C | Adley Rutschman | Bal | 6 | NYA(3) KC(3) |
| 1B | Willson Contreras | StL | 9 | @Cin(5) NYN(4) |
| 2B | Brandon Lowe | TB | 6 | KC(3) @NYA(3) |
| SS | Geraldo Perdomo | Ari | 6 | @NYN(3) @Phi(3) |
| 3B | Jose Ramirez | Cle | 7 | Min(4) @Tor(3) |
| OF | Lourdes Gurriel | Ari | 6 | @NYN(3) @Phi(3) |
| OF | Matt Wallner | Min | 7 | @Cle(4) @Bos(3) |
| OF | Michael Conforto | LAD | 6 | Mia(3) @Atl(3) |
| DH (OF) | Anthony Santander | Tor | 6 | Bos(3) Cle(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Carson Kelly | ChN | 6 | @Pit(3) @Mil(3) |
| 1B | Ryan Mountcastle | Bal | 6 | NYA(3) KC(3) |
| 2B | Jackson Holliday | Bal | 6 | NYA(3) KC(3) |
| SS (3B) | Joey Ortiz | Mil | 6 | @ChA(3) ChN(3) |
| 3B | Junior Caminero | TB | 6 | KC(3) @NYA(3) |
| OF | Jo Adell | LAA | 6 | @Sea(2) Det(4) |
| DH (1B) | Carlos Santana | Cle | 7 | Min(4) @Tor(3) |
| Position | Bench | Team | Games | Opponents |
| SS (2B) | Tyler Freeman | Col | 7 | Atl(3) @SF(4) |
| SS (3B) | Jose Tena | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| 3B | Luis Urias | Oak | 7 | @Tex(4) @Mia(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Paul Skenes | Pit | 6 | ChN(3) SD(3) | Last Pitched Thursday May 1st |
| 2nd SP | Jacob deGrom | Tex | 7 | Oak(4) Sea(3) | This Sunday vs Sea (Logan Evans) |
| 3rd SP | Gavin Williams | Cle | 7 | Min(4) @Tor(3) | Last Pitched Saturday May 3rd |
| 4th SP | Yoshinobu Yamamoto | LAD | 6 | Mia(3) @Atl(3) | Last Pitched Friday May 2nd |
| 5th SP | Jackson Jobe | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Wednesday April 30th |
| 6th SP | Nick Pivetta | SD | 5 | SF(2) @Pit(3) | Last Pitched Tuesday April 29th |
| 7th SP | Yusei Kikuchi | LAA | 6 | @Sea(2) Det(4) | Last Pitched Thursday May 1st |
| 8th SP | Cody Bradford | Tex | 7 | Oak(4) Sea(3) | Has Not Played Yet |
| 9th SP | Bobby Miller | LAD | 6 | Mia(3) @Atl(3) | Last Pitched Wednesday April 16th |
| 1st RP | Andres Munoz | Sea | 5 | LAA(2) @Tex(3) | Last Pitched Saturday May 3rd |
| 2nd RP | Mason Miller | Oak | 7 | @Tex(4) @Mia(3) | Last Pitched Saturday May 3rd |
| 3rd RP | Porter Hodge | ChN | 6 | @Pit(3) @Mil(3) | Last Pitched Thursday May 1st |
| Position | Injured List | Team | Games | Opponents |
| SP | Alexander Cobb | Det | 7 | @Hou(3) @LAA(4) |
| SP | Spencer Arrighetti | Hou | 6 | Det(3) @ChA(3) |