| Position | Starters | Team | Games | Opponents |
| C | Yainer Diaz | Hou | 6 | Det(3) @ChA(3) |
| 1B | Matt Olson | Atl | 6 | @Col(3) LAD(3) |
| 2B | Marcus Semien | Tex | 7 | Oak(4) Sea(3) |
| SS | Dansby Swanson | ChN | 6 | @Pit(3) @Mil(3) |
| 3B | Jordan Westburg | Bal | 6 | NYA(3) KC(3) |
| OF | Steven Kwan | Cle | 7 | Min(4) @Tor(3) |
| OF | Michael Harris II | Atl | 6 | @Col(3) LAD(3) |
| OF | Fernando Tatis Jr. | SD | 5 | SF(2) @Pit(3) |
| DH (3B,2B) | Dylan Moore | Sea | 5 | LAA(2) @Tex(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Gabriel Moreno | Ari | 6 | @NYN(3) @Phi(3) |
| 1B | Eric Wagaman | Mia | 6 | @LAD(3) Oak(3) |
| SS | Jeremy Pena | Hou | 6 | Det(3) @ChA(3) |
| OF | Jasson Dominguez | NYA | 6 | @Bal(3) TB(3) |
| DH (SS) | Xavier Edwards | Mia | 6 | @LAD(3) Oak(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| OF | Victor Scott | StL | 9 | @Cin(5) NYN(4) |
| Position | 3rd Backup | Team | Games | Opponents |
| OF | Daulton Varsho | Tor | 6 | Bos(3) Cle(3) |
| Position | Bench | Team | Games | Opponents |
| 1B | Luis Arraez | SD | 5 | SF(2) @Pit(3) |
| SS | Masyn Winn | StL | 9 | @Cin(5) NYN(4) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Garrett Crochet | Bos | 6 | @Tor(3) Min(3) | This Sunday vs Min (Chris Paddack) |
| 2nd SP | Shota Imanaga | ChN | 6 | @Pit(3) @Mil(3) | This Sunday at Mil (Freddy Peralta) |
| 3rd SP | Hunter Greene | Cin | 8 | StL(5) Was(3) | Last Pitched Friday May 2nd |
| 4th SP | Sonny Gray | StL | 9 | @Cin(5) NYN(4) | Last Pitched Friday May 2nd |
| 5th SP | Joe Ryan | Min | 7 | @Cle(4) @Bos(3) | Last Pitched Friday May 2nd |
| 6th SP | Pablo Lopez | Min | 7 | @Cle(4) @Bos(3) | Last Pitched Wednesday April 30th |
| 7th SP | Brandon Pfaadt | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Saturday May 3rd |
| 8th SP | Bailey Ober | Min | 7 | @Cle(4) @Bos(3) | Last Pitched Saturday May 3rd |
| 9th SP | Chris Bassitt | Tor | 6 | Bos(3) Cle(3) | Last Pitched Friday May 2nd |
| 10th SP | Ryan Pepiot | TB | 6 | KC(3) @NYA(3) | Last Pitched Friday May 2nd |
| 11th SP | Shane Smith | ChA | 6 | Mil(3) Hou(3) | Last Pitched Wednesday April 30th |
| 1st RP | Josh Hader | Hou | 6 | Det(3) @ChA(3) | Last Pitched Tuesday April 29th |
| 2nd RP | Felix Bautista | Bal | 6 | NYA(3) KC(3) | Last Pitched Friday May 2nd |
| Position | Injured List | Team | Games | Opponents |
| SP | Nestor Cortes Jr. | Mil | 6 | @ChA(3) ChN(3) |
| SP | Gerrit Cole | NYA | 6 | @Bal(3) TB(3) |
| OF | Parker Meadows | Det | 7 | @Hou(3) @LAA(4) |