| Position | Starters | Team | Games | Opponents |
| C | Cal Raleigh | Sea | 5 | LAA(2) @Tex(3) |
| 1B | Vinnie Pasquantino | KC | 6 | @TB(3) @Bal(3) |
| 2B | Brice Turang | Mil | 6 | @ChA(3) ChN(3) |
| SS | Willy Adames | SF | 6 | @SD(2) Col(4) |
| 3B | Rafael Devers | Bos | 6 | @Tor(3) Min(3) |
| OF | Seiya Suzuki | ChN | 6 | @Pit(3) @Mil(3) |
| OF | Aaron Judge | NYA | 6 | @Bal(3) TB(3) |
| OF | Nick Castellanos | Phi | 6 | Was(3) Ari(3) |
| DH (OF) | Mike Trout | LAA | 6 | @Sea(2) Det(4) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Jonah Heim | Tex | 7 | Oak(4) Sea(3) |
| 1B | Nolan Schanuel | LAA | 6 | @Sea(2) Det(4) |
| 2B | Gavin Lux | Cin | 8 | StL(5) Was(3) |
| SS | Zach Neto | LAA | 6 | @Sea(2) Det(4) |
| 3B | Josh Smith | Tex | 7 | Oak(4) Sea(3) |
| OF | Ceddanne Rafaela | Bos | 6 | @Tor(3) Min(3) |
| DH (2B) | Andrés Gimenez | Tor | 6 | Bos(3) Cle(3) |
| Position | Bench | Team | Games | Opponents |
| OF | Victor Robles | Sea | 5 | LAA(2) @Tex(3) |
| DH (2B) | Max Muncy | Oak | 7 | @Tex(4) @Mia(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Tyler Glasnow | LAD | 6 | Mia(3) @Atl(3) | Last Pitched Sunday April 27th |
| 2nd SP | Cole Ragans | KC | 6 | @TB(3) @Bal(3) | Last Pitched Thursday April 24th |
| 3rd SP | Aaron Nola | Phi | 6 | Was(3) Ari(3) | Last Pitched Saturday May 3rd |
| 4th SP | Zac Gallen | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Thursday May 1st |
| 5th SP | Jameson Taillon | ChN | 6 | @Pit(3) @Mil(3) | Last Pitched Saturday May 3rd |
| 6th SP | Brayan Bello | Bos | 6 | @Tor(3) Min(3) | Last Pitched Friday May 2nd |
| 7th SP | Mitch Keller | Pit | 6 | ChN(3) SD(3) | Last Pitched Friday May 2nd |
| 8th SP | Matt Boyd | ChN | 6 | @Pit(3) @Mil(3) | Last Pitched Wednesday April 30th |
| 9th SP | Bubba Chandler | Pit | 6 | ChN(3) SD(3) | Has Not Played Yet |
| 10th SP | Ben Brown | ChN | 6 | @Pit(3) @Mil(3) | Last Pitched Friday May 2nd |
| 1st RP | Emmanuel Clase | Cle | 7 | Min(4) @Tor(3) | Last Pitched Saturday May 3rd |
| 2nd RP | Will Vest | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Tuesday April 29th |
| 3rd RP | Justin Martinez | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Games | Opponents |
| SP | Justin Steele | ChN | 6 | @Pit(3) @Mil(3) |
| SS | Ha-seong Kim | TB | 6 | KC(3) @NYA(3) |
| C | Tyler Stephenson | Cin | 8 | StL(5) Was(3) |