| Position | Starters | Team | Games | Opponents |
| C | Drake Baldwin | Atl | 6 | @Col(3) LAD(3) |
| 1B | Tyler Soderstrom | Oak | 7 | @Tex(4) @Mia(3) |
| 2B | Kristian Campbell | Bos | 6 | @Tor(3) Min(3) |
| SS | Carlos Correa | Min | 7 | @Cle(4) @Bos(3) |
| 3B | Noelvi Marte | Cin | 8 | StL(5) Was(3) |
| OF | Pete Crow-Armstrong | ChN | 6 | @Pit(3) @Mil(3) |
| OF | Jung Hoo Lee | SF | 6 | @SD(2) Col(4) |
| OF | Lars Nootbaar | StL | 9 | @Cin(5) NYN(4) |
| DH (1B) | Kyle Manzardo | Cle | 7 | Min(4) @Tor(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Alejandro Kirk | Tor | 6 | Bos(3) Cle(3) |
| 1B | Jake Burger | Tex | 7 | Oak(4) Sea(3) |
| 2B | Gleyber Torres | Det | 7 | @Hou(3) @LAA(4) |
| SS | J.P. Crawford | Sea | 5 | LAA(2) @Tex(3) |
| 3B | Max Muncy | LAD | 6 | Mia(3) @Atl(3) |
| OF | Mike Yastrzemski | SF | 6 | @SD(2) Col(4) |
| DH (2B) | Thomas Saggese | StL | 9 | @Cin(5) NYN(4) |
| Position | 2nd Backup | Team | Games | Opponents |
| OF | Chandler Simpson | TB | 6 | KC(3) @NYA(3) |
| DH (SS,2B) | Adael Amador | Col | 7 | Atl(3) @SF(4) |
| Position | Bench | Team | Games | Opponents |
| OF | Colton Cowser | Bal | 6 | NYA(3) KC(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Sandy Alcantara | Mia | 6 | @LAD(3) Oak(3) | Last Pitched Tuesday April 29th |
| 2nd SP | Spencer Schwellenbach | Atl | 6 | @Col(3) LAD(3) | Last Pitched Saturday May 3rd |
| 3rd SP | Tylor Megill | NYN | 8 | @Was(1) Ari(3) @StL(4) | This Sunday at StL (Andre Pallante) |
| 4th SP | Jeffrey Springs | Oak | 7 | @Tex(4) @Mia(3) | Last Pitched Thursday May 1st |
| 5th SP | Andrew Abbott | Cin | 8 | StL(5) Was(3) | Last Pitched Thursday May 1st |
| 6th SP | Landen Roupp | SF | 6 | @SD(2) Col(4) | Last Pitched Wednesday April 30th |
| 7th SP | Griffin Canning | NYN | 8 | @Was(1) Ari(3) @StL(4) | Last Pitched Monday April 28th |
| 8th SP | Osvaldo Bido | Oak | 7 | @Tex(4) @Mia(3) | Last Pitched Saturday May 3rd |
| 9th SP | Kumar Rocker | Tex | 7 | Oak(4) Sea(3) | Last Pitched Wednesday April 23rd |
| 10th SP | Andrew Painter | Phi | 6 | Was(3) Ari(3) | Has Not Played Yet |
| 1st RP | Ryan Helsley | StL | 9 | @Cin(5) NYN(4) | Last Pitched Friday May 2nd |
| 2nd RP | Alexis Diaz | Cin | 8 | StL(5) Was(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Games | Opponents |
| 3B | Royce Lewis | Min | 7 | @Cle(4) @Bos(3) |
| 2B | Zack Gelof | Oak | 7 | @Tex(4) @Mia(3) |
| C | Ivan Herrera | StL | 9 | @Cin(5) NYN(4) |