| Position | Starters | Team | Games | Opponents |
| C | Sean Murphy | Atl | 6 | @Col(3) LAD(3) |
| 1B | Freddie Freeman | LAD | 6 | Mia(3) @Atl(3) |
| 2B | Kristian Campbell | Bos | 6 | @Tor(3) Min(3) |
| SS | Mookie Betts | LAD | 6 | Mia(3) @Atl(3) |
| 3B | Rafael Devers | Bos | 6 | @Tor(3) Min(3) |
| OF | Jarren Duran | Bos | 6 | @Tor(3) Min(3) |
| OF | Yordan Alvarez | Hou | 6 | Det(3) @ChA(3) |
| OF (2B) | Tommy Edman | LAD | 6 | Mia(3) @Atl(3) |
| DH (SS) | Bobby Witt Jr. | KC | 6 | @TB(3) @Bal(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Gabriel Moreno | Ari | 6 | @NYN(3) @Phi(3) |
| 1B | Kyle Manzardo | Cle | 7 | Min(4) @Tor(3) |
| 2B | Christian Moore | LAA | 6 | @Sea(2) Det(4) |
| SS | Jacob Wilson | Oak | 7 | @Tex(4) @Mia(3) |
| 3B (SS) | Joey Ortiz | Mil | 6 | @ChA(3) ChN(3) |
| OF | Roman Anthony | Bos | 6 | @Tor(3) Min(3) |
| DH (1B) | Nick Kurtz | Oak | 7 | @Tex(4) @Mia(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| 2B | Travis Bazzana | Cle | 7 | Min(4) @Tor(3) |
| SS | Sebastian Walcott | Tex | 7 | Oak(4) Sea(3) |
| OF | Michael Conforto | LAD | 6 | Mia(3) @Atl(3) |
| DH (OF) | Walker Jenkins | Min | 7 | @Cle(4) @Bos(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Pablo Lopez | Min | 7 | @Cle(4) @Bos(3) | Last Pitched Wednesday April 30th |
| 2nd SP | Sandy Alcantara | Mia | 6 | @LAD(3) Oak(3) | Last Pitched Tuesday April 29th |
| 3rd SP | Clay Holmes | NYN | 8 | @Was(1) Ari(3) @StL(4) | Last Pitched Friday May 2nd |
| 4th SP | Drew Rasmussen | TB | 6 | KC(3) @NYA(3) | Last Pitched Wednesday April 30th |
| 5th SP | Jackson Jobe | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Wednesday April 30th |
| 6th SP | Jose Quintana | Mil | 6 | @ChA(3) ChN(3) | Last Pitched Saturday May 3rd |
| 7th SP | Reese Olson | Det | 7 | @Hou(3) @LAA(4) | This Sunday at LAA (Jack Kochanowicz) |
| 8th SP | Grant Holmes | Atl | 6 | @Col(3) LAD(3) | Last Pitched Friday May 2nd |
| 1st RP | Tanner Scott | LAD | 6 | Mia(3) @Atl(3) | Last Pitched Friday May 2nd |
| 2nd RP | Kyle Finnegan | Was | 7 | NYN(1) @Phi(3) @Cin(3) | Last Pitched Thursday May 1st |
| 3rd RP | Justin Martinez | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Games | Opponents |
| SP | Spencer Arrighetti | Hou | 6 | Det(3) @ChA(3) |
| SP | Clayton Kershaw | LAD | 6 | Mia(3) @Atl(3) |
| SP | Zach Eflin | Bal | 6 | NYA(3) KC(3) |