| Position | Starters | Team | Games | Opponents |
| C | Carson Kelly | ChN | 6 | @Pit(3) @Mil(3) |
| 1B | Vladimir Guerrero Jr. | Tor | 6 | Bos(3) Cle(3) |
| 2B | Marcus Semien | Tex | 7 | Oak(4) Sea(3) |
| SS | Francisco Lindor | NYN | 8 | @Was(1) Ari(3) @StL(4) |
| 3B | Jose Ramirez | Cle | 7 | Min(4) @Tor(3) |
| OF | Jordan Beck | Col | 7 | Atl(3) @SF(4) |
| OF | Jackson Merrill | SD | 5 | SF(2) @Pit(3) |
| OF | Byron Buxton | Min | 7 | @Cle(4) @Bos(3) |
| DH (3B) | Jorge Polanco | Sea | 5 | LAA(2) @Tex(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Yainer Diaz | Hou | 6 | Det(3) @ChA(3) |
| 1B | Ryan Mountcastle | Bal | 6 | NYA(3) KC(3) |
| 2B (OF) | Angel Martinez | Cle | 7 | Min(4) @Tor(3) |
| SS | Marcelo Mayer | Bos | 6 | @Tor(3) Min(3) |
| 3B | Caleb Durbin | Mil | 6 | @ChA(3) ChN(3) |
| OF | Ceddanne Rafaela | Bos | 6 | @Tor(3) Min(3) |
| DH (SS,2B,OF) | Kyren Paris | LAA | 6 | @Sea(2) Det(4) |
| Position | 2nd Backup | Team | Games | Opponents |
| 1B | Bryce Eldridge | SF | 6 | @SD(2) Col(4) |
| OF | Heston Kjerstad | Bal | 6 | NYA(3) KC(3) |
| Position | 3rd Backup | Team | Games | Opponents |
| OF | Tyler O'Neill | Bal | 6 | NYA(3) KC(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Zack Wheeler | Phi | 6 | Was(3) Ari(3) | Last Pitched Tuesday April 29th |
| 2nd SP | Logan Webb | SF | 6 | @SD(2) Col(4) | This Sunday vs Col (Germán Márquez) |
| 3rd SP | Chris Sale | Atl | 6 | @Col(3) LAD(3) | Last Pitched Wednesday April 30th |
| 4th SP | Gavin Williams | Cle | 7 | Min(4) @Tor(3) | Last Pitched Saturday May 3rd |
| 5th SP | Bubba Chandler | Pit | 6 | ChN(3) SD(3) | Has Not Played Yet |
| 6th SP | Dustin May | LAD | 6 | Mia(3) @Atl(3) | This Sunday at Atl (Bryce Elder) |
| 7th SP | Ronel Blanco | Hou | 6 | Det(3) @ChA(3) | Last Pitched Monday April 28th |
| 8th SP | Landen Roupp | SF | 6 | @SD(2) Col(4) | Last Pitched Wednesday April 30th |
| 9th SP | Andrew Painter | Phi | 6 | Was(3) Ari(3) | Has Not Played Yet |
| 10th SP | Zebby Matthews | Min | 7 | @Cle(4) @Bos(3) | Has Not Played Yet |
| 1st RP | Aroldis Chapman | Bos | 6 | @Tor(3) Min(3) | Last Pitched Wednesday April 30th |
| 2nd RP | José Alvarado | Phi | 6 | Was(3) Ari(3) | Last Pitched Friday May 2nd |
| Position | Injured List | Team | Games | Opponents |
| SP | Eury Perez | Mia | 6 | @LAD(3) Oak(3) |
| SP | Shane McClanahan | TB | 6 | KC(3) @NYA(3) |
| DH | Colton Cowser | Bal | 6 | NYA(3) KC(3) |