| Position | Starters | Team | Games | Opponents |
| C | Cal Raleigh | Sea | 5 | LAA(2) @Tex(3) |
| 1B | Jake Burger | Tex | 7 | Oak(4) Sea(3) |
| 2B | Brandon Lowe | TB | 6 | KC(3) @NYA(3) |
| SS | Willy Adames | SF | 6 | @SD(2) Col(4) |
| 3B | Mark Vientos | NYN | 8 | @Was(1) Ari(3) @StL(4) |
| OF | Teoscar Hernández | LAD | 6 | Mia(3) @Atl(3) |
| OF | Anthony Santander | Tor | 6 | Bos(3) Cle(3) |
| OF | TJ Friedl | Cin | 8 | StL(5) Was(3) |
| DH (OF) | Alex Verdugo | Atl | 6 | @Col(3) LAD(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Bo Naylor | Cle | 7 | Min(4) @Tor(3) |
| 1B | Ty France | Min | 7 | @Cle(4) @Bos(3) |
| 2B (3B,OF) | Maikel Garcia | KC | 6 | @TB(3) @Bal(3) |
| SS | Gabriel Arias | Cle | 7 | Min(4) @Tor(3) |
| 3B | Josh Smith | Tex | 7 | Oak(4) Sea(3) |
| OF | Adolis Garcia | Tex | 7 | Oak(4) Sea(3) |
| DH (OF) | George Springer | Tor | 6 | Bos(3) Cle(3) |
| Position | Bench | Team | Games | Opponents |
| 2B | Jeff McNeil | NYN | 8 | @Was(1) Ari(3) @StL(4) |
| OF | Kyle Stowers | Mia | 6 | @LAD(3) Oak(3) |
| OF | Jorge Soler | LAA | 6 | @Sea(2) Det(4) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Cole Ragans | KC | 6 | @TB(3) @Bal(3) | Last Pitched Thursday April 24th |
| 2nd SP | Aaron Nola | Phi | 6 | Was(3) Ari(3) | Last Pitched Saturday May 3rd |
| 3rd SP | Seth Lugo | KC | 6 | @TB(3) @Bal(3) | Last Pitched Thursday May 1st |
| 4th SP | Jose Berrios | Tor | 6 | Bos(3) Cle(3) | Last Pitched Thursday May 1st |
| 5th SP | Jameson Taillon | ChN | 6 | @Pit(3) @Mil(3) | Last Pitched Saturday May 3rd |
| 6th SP | Mitchell Parker | Was | 7 | NYN(1) @Phi(3) @Cin(3) | Last Pitched Friday May 2nd |
| 7th SP | Hayden Wesneski | Hou | 6 | Det(3) @ChA(3) | Last Pitched Friday April 25th |
| 8th SP | Tomoyuki Sugano | Bal | 6 | NYA(3) KC(3) | Last Pitched Saturday May 3rd |
| 9th SP | Jake Irvin | Was | 7 | NYN(1) @Phi(3) @Cin(3) | Last Pitched Wednesday April 30th |
| 1st RP | Raisel Iglesias | Atl | 6 | @Col(3) LAD(3) | Last Pitched Saturday May 3rd |
| 2nd RP | Ryan Pressly | ChN | 6 | @Pit(3) @Mil(3) | Last Pitched Thursday May 1st |
| 3rd RP | Trevor Megill | Mil | 6 | @ChA(3) ChN(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Games | Opponents |
| SP | Gerrit Cole | NYA | 6 | @Bal(3) TB(3) |
| 2B | Jake Cronenworth | SD | 5 | SF(2) @Pit(3) |