| Position | Starters | Team | Games | Opponents |
| C | Will Smith | LAD | 6 | Mia(3) @Atl(3) |
| 1B | Ryan O'Hearn | Bal | 6 | NYA(3) KC(3) |
| 2B (OF) | Gavin Lux | Cin | 8 | StL(5) Was(3) |
| SS | Anthony Volpe | NYA | 6 | @Bal(3) TB(3) |
| 3B | Noelvi Marte | Cin | 8 | StL(5) Was(3) |
| OF | Pete Crow-Armstrong | ChN | 6 | @Pit(3) @Mil(3) |
| OF | Julio Rodriguez | Sea | 5 | LAA(2) @Tex(3) |
| OF | Chandler Simpson | TB | 6 | KC(3) @NYA(3) |
| DH (C) | Agustin Ramirez | Mia | 6 | @LAD(3) Oak(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Ryan Jeffers | Min | 7 | @Cle(4) @Bos(3) |
| 1B | Vinnie Pasquantino | KC | 6 | @TB(3) @Bal(3) |
| 2B (3B) | Jordan Westburg | Bal | 6 | NYA(3) KC(3) |
| SS | J.P. Crawford | Sea | 5 | LAA(2) @Tex(3) |
| 3B (OF) | Cam Smith | Hou | 6 | Det(3) @ChA(3) |
| OF | Michael Harris II | Atl | 6 | @Col(3) LAD(3) |
| DH (OF) | Dylan Crews | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| OF | Victor Scott | StL | 9 | @Cin(5) NYN(4) |
| DH (OF) | Andrew Benintendi | ChA | 6 | Mil(3) Hou(3) |
| Position | Bench | Team | Games | Opponents |
| OF | Jordan Walker | StL | 9 | @Cin(5) NYN(4) |
| OF | Evan Carter | Tex | 7 | Oak(4) Sea(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Max Fried | NYA | 6 | @Bal(3) TB(3) | Last Pitched Friday May 2nd |
| 2nd SP | Bryan Woo | Sea | 5 | LAA(2) @Tex(3) | Last Pitched Friday May 2nd |
| 3rd SP | Max Meyer | Mia | 6 | @LAD(3) Oak(3) | Last Pitched Saturday May 3rd |
| 4th SP | Andrew Abbott | Cin | 8 | StL(5) Was(3) | Last Pitched Thursday May 1st |
| 5th SP | Tyler Anderson | LAA | 6 | @Sea(2) Det(4) | Last Pitched Wednesday April 30th |
| 6th SP | Jack Leiter | Tex | 7 | Oak(4) Sea(3) | Last Pitched Friday May 2nd |
| 7th SP | Roki Sasaki | LAD | 6 | Mia(3) @Atl(3) | Last Pitched Saturday May 3rd |
| 8th SP | Justin Verlander | SF | 6 | @SD(2) Col(4) | Last Pitched Thursday May 1st |
| 1st RP | Carlos Estevez | KC | 6 | @TB(3) @Bal(3) | Last Pitched Wednesday April 30th |
| 2nd RP | Luke Jackson | Tex | 7 | Oak(4) Sea(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Games | Opponents |
| SP | Ryan Weathers | Mia | 6 | @LAD(3) Oak(3) |
| 3B | Royce Lewis | Min | 7 | @Cle(4) @Bos(3) |
| 1B | Christian Encarnacion-Strand | Cin | 8 | StL(5) Was(3) |