| Position | Starters | Team | Games | Opponents |
| C | Francisco Álvarez | NYN | 7 | @Was(1) Ari(3) @StL(3) |
| 1B | Pete Alonso | NYN | 7 | @Was(1) Ari(3) @StL(3) |
| 2B | Tyler Fitzgerald | SF | 6 | @SD(2) Col(4) |
| SS | Elly De La Cruz | Cin | 8 | StL(5) Was(3) |
| 3B | Alex Bregman | Bos | 6 | @Tor(3) Min(3) |
| OF | Dylan Crews | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| OF | Jackson Chourio | Mil | 6 | @ChA(3) ChN(3) |
| OF | Byron Buxton | Min | 7 | @Cle(4) @Bos(3) |
| DH (SS) | Bo Bichette | Tor | 6 | Bos(3) Cle(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Will Smith | LAD | 6 | Mia(3) @Atl(3) |
| 1B | Willson Contreras | StL | 8 | @Cin(5) NYN(3) |
| 2B (SS) | Gabriel Arias | Cle | 7 | Min(4) @Tor(3) |
| SS | Jeremy Pena | Hou | 6 | Det(3) @ChA(3) |
| 3B | Caleb Durbin | Mil | 6 | @ChA(3) ChN(3) |
| OF | Sal Frelick | Mil | 6 | @ChA(3) ChN(3) |
| DH (OF) | Kameron Misner | TB | 6 | KC(3) @NYA(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| OF | JJ Bleday | Oak | 7 | @Tex(4) @Mia(3) |
| DH (OF) | Jordan Beck | Col | 7 | Atl(3) @SF(4) |
| Position | Bench | Team | Games | Opponents |
| C | Austin Wells | NYA | 6 | @Bal(3) TB(3) |
| OF | Jordan Walker | StL | 8 | @Cin(5) NYN(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Hunter Brown | Hou | 6 | Det(3) @ChA(3) | This Saturday at ChA (Davis Martin) |
| 2nd SP | Casey Mize | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Thursday May 1st |
| 3rd SP | Tyler Mahle | Tex | 7 | Oak(4) Sea(3) | Last Pitched Thursday May 1st |
| 4th SP | Brayan Bello | Bos | 6 | @Tor(3) Min(3) | Last Pitched Friday May 2nd |
| 5th SP | Clay Holmes | NYN | 7 | @Was(1) Ari(3) @StL(3) | Last Pitched Friday May 2nd |
| 6th SP | Mitchell Parker | Was | 7 | NYN(1) @Phi(3) @Cin(3) | Last Pitched Friday May 2nd |
| 7th SP | Dustin May | LAD | 6 | Mia(3) @Atl(3) | This Sunday at Atl (Bryce Elder) |
| 8th SP | Jackson Jobe | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Wednesday April 30th |
| 1st RP | Mason Miller | Oak | 7 | @Tex(4) @Mia(3) | Last Pitched Thursday May 1st |
| 2nd RP | Ryan Helsley | StL | 8 | @Cin(5) NYN(3) | Last Pitched Friday May 2nd |
| 3rd RP | Luke Jackson | Tex | 7 | Oak(4) Sea(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Games | Opponents |
| 2B | Zack Gelof | Oak | 7 | @Tex(4) @Mia(3) |
| 2B | Jake Cronenworth | SD | 5 | SF(2) @Pit(3) |
| OF | Ronald Acuna Jr. | Atl | 6 | @Col(3) LAD(3) |