| Position | Starters | Team | Games | Opponents |
| C | Cal Raleigh | Sea | 5 | LAA(2) @Tex(3) |
| 1B (OF) | Pavin Smith | Ari | 6 | @NYN(3) @Phi(3) |
| 2B | Wilmer Flores | SF | 6 | @SD(2) Col(4) |
| SS | Geraldo Perdomo | Ari | 6 | @NYN(3) @Phi(3) |
| 3B | Jose Ramirez | Cle | 7 | Min(4) @Tor(3) |
| OF | Cedric Mullins II | Bal | 6 | NYA(3) KC(3) |
| OF | Randy Arozarena | Sea | 5 | LAA(2) @Tex(3) |
| OF | Taylor Ward | LAA | 6 | @Sea(2) Det(4) |
| DH (OF) | Wilyer Abreu | Bos | 6 | @Tor(3) Min(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Gabriel Moreno | Ari | 6 | @NYN(3) @Phi(3) |
| 1B | Jake Burger | Tex | 7 | Oak(4) Sea(3) |
| 2B | Andrés Gimenez | Tor | 6 | Bos(3) Cle(3) |
| SS | Willy Adames | SF | 6 | @SD(2) Col(4) |
| 3B | Jorge Polanco | Sea | 5 | LAA(2) @Tex(3) |
| OF | Jorge Soler | LAA | 6 | @Sea(2) Det(4) |
| DH (1B) | Andrew Vaughn | ChA | 6 | Mil(3) Hou(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| OF | Heston Kjerstad | Bal | 6 | NYA(3) KC(3) |
| DH (3B) | Ryan McMahon | Col | 7 | Atl(3) @SF(4) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Luis Castillo | Sea | 5 | LAA(2) @Tex(3) | This Saturday at Tex (Pat Corbin) |
| 2nd SP | Freddy Peralta | Mil | 6 | @ChA(3) ChN(3) | This Sunday vs ChN (Shota Imanaga) |
| 3rd SP | Sonny Gray | StL | 8 | @Cin(5) NYN(3) | Last Pitched Friday May 2nd |
| 4th SP | Eduardo Rodriguez | Ari | 6 | @NYN(3) @Phi(3) | This Sunday at Phi (Ranger Suarez) |
| 5th SP | Merrill Kelly | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Friday May 2nd |
| 6th SP | Mike Lorenzen | KC | 6 | @TB(3) @Bal(3) | This Sunday at Bal (Kyle Gibson) |
| 7th SP | Tanner Houck | Bos | 6 | @Tor(3) Min(3) | Last Pitched Thursday May 1st |
| 8th SP | Ryan Pepiot | TB | 6 | KC(3) @NYA(3) | Last Pitched Friday May 2nd |
| 9th SP | Jake Irvin | Was | 7 | NYN(1) @Phi(3) @Cin(3) | Last Pitched Wednesday April 30th |
| 10th SP | Logan Allen | Cle | 7 | Min(4) @Tor(3) | Last Pitched Friday May 2nd |
| 1st RP | Emmanuel Clase | Cle | 7 | Min(4) @Tor(3) | Last Pitched Wednesday April 30th |
| 2nd RP | Kyle Finnegan | Was | 7 | NYN(1) @Phi(3) @Cin(3) | Last Pitched Thursday May 1st |
| 3rd RP | Devin Williams | NYA | 6 | @Bal(3) TB(3) | Last Pitched Friday May 2nd |
| Position | Injured List | Team | Games | Opponents |
| SP | Blake Snell | LAD | 6 | Mia(3) @Atl(3) |
| 2B | Ketel Marte | Ari | 6 | @NYN(3) @Phi(3) |