| Position | Starters | Team | Games | Opponents |
| C | Agustin Ramirez | Mia | 6 | @LAD(3) Oak(3) |
| 1B | Vladimir Guerrero Jr. | Tor | 6 | Bos(3) Cle(3) |
| 2B (OF) | Jose Altuve | Hou | 6 | Det(3) @ChA(3) |
| SS | Trey Sweeney | Det | 7 | @Hou(3) @LAA(4) |
| 3B | Max Muncy | LAD | 6 | Mia(3) @Atl(3) |
| OF | Adolis Garcia | Tex | 7 | Oak(4) Sea(3) |
| OF | Oneil Cruz | Pit | 6 | ChN(3) SD(3) |
| OF | Julio Rodriguez | Sea | 5 | LAA(2) @Tex(3) |
| DH (1B) | Tyler Soderstrom | Oak | 7 | @Tex(4) @Mia(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Yainer Diaz | Hou | 6 | Det(3) @ChA(3) |
| 1B | Michael Toglia | Col | 7 | Atl(3) @SF(4) |
| 2B (OF) | Kristian Campbell | Bos | 6 | @Tor(3) Min(3) |
| SS (2B,OF) | Kyren Paris | LAA | 6 | @Sea(2) Det(4) |
| 3B (OF) | Cam Smith | Hou | 6 | Det(3) @ChA(3) |
| OF | Jung Hoo Lee | SF | 6 | @SD(2) Col(4) |
| DH (3B) | Noelvi Marte | Cin | 8 | StL(5) Was(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| OF | Heliot Ramos | SF | 6 | @SD(2) Col(4) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Michael King | SD | 5 | SF(2) @Pit(3) | Last Pitched Wednesday April 30th |
| 2nd SP | Jesus Luzardo | Phi | 6 | Was(3) Ari(3) | Last Pitched Friday May 2nd |
| 3rd SP | Pablo Lopez | Min | 7 | @Cle(4) @Bos(3) | Last Pitched Wednesday April 30th |
| 4th SP | Zac Gallen | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Thursday May 1st |
| 5th SP | Matt Boyd | ChN | 6 | @Pit(3) @Mil(3) | Last Pitched Wednesday April 30th |
| 6th SP | Mitch Keller | Pit | 6 | ChN(3) SD(3) | Last Pitched Friday May 2nd |
| 7th SP | Tanner Bibee | Cle | 7 | Min(4) @Tor(3) | This Sunday at Tor (Bowden Francis) |
| 8th SP | Andrew Abbott | Cin | 8 | StL(5) Was(3) | Last Pitched Thursday May 1st |
| 9th SP | Reese Olson | Det | 7 | @Hou(3) @LAA(4) | This Sunday at LAA (Jack Kochanowicz) |
| 10th SP | Yusei Kikuchi | LAA | 6 | @Sea(2) Det(4) | Last Pitched Thursday May 1st |
| 11th SP | Jack Leiter | Tex | 7 | Oak(4) Sea(3) | Last Pitched Friday May 2nd |
| 12th SP | Bubba Chandler | Pit | 6 | ChN(3) SD(3) | Has Not Played Yet |
| 1st RP | Carlos Estevez | KC | 6 | @TB(3) @Bal(3) | Last Pitched Wednesday April 30th |
| 2nd RP | Tanner Scott | LAD | 6 | Mia(3) @Atl(3) | Last Pitched Friday May 2nd |
| Position | Injured List | Team | Games | Opponents |
| SS | Corey Seager | Tex | 7 | Oak(4) Sea(3) |
| DH | Daulton Varsho | Tor | 6 | Bos(3) Cle(3) |
| 2B | Luke Keaschall | Min | 7 | @Cle(4) @Bos(3) |