| Position | Starters | Team | Games | Opponents |
| C | Cal Raleigh | Sea | 5 | LAA(2) @Tex(3) |
| 1B | Pete Alonso | NYN | 7 | @Was(1) Ari(3) @StL(3) |
| 2B | Marcus Semien | Tex | 7 | Oak(4) Sea(3) |
| SS | Bobby Witt Jr. | KC | 6 | @TB(3) @Bal(3) |
| 3B | Austin Riley | Atl | 6 | @Col(3) LAD(3) |
| OF | Daulton Varsho | Tor | 6 | Bos(3) Cle(3) |
| OF | Jorge Soler | LAA | 6 | @Sea(2) Det(4) |
| OF | JJ Bleday | Oak | 7 | @Tex(4) @Mia(3) |
| DH | Marcell Ozuna | Atl | 6 | @Col(3) LAD(3) |
| Position | 1st Backup | Team | Games | Opponents |
| 1B | Paul Goldschmidt | NYA | 6 | @Bal(3) TB(3) |
| 3B | Matt Shaw | ChN | 6 | @Pit(3) @Mil(3) |
| OF | Lars Nootbaar | StL | 8 | @Cin(5) NYN(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| 1B | Michael Toglia | Col | 7 | Atl(3) @SF(4) |
| OF | Jung Hoo Lee | SF | 6 | @SD(2) Col(4) |
| Position | Bench | Team | Games | Opponents |
| 1B | Spencer Torkelson | Det | 7 | @Hou(3) @LAA(4) |
| Pitching Staff Alignment |
| 5 Starts, 3 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Logan Webb | SF | 6 | @SD(2) Col(4) | This Sunday vs Col (Germán Márquez) |
| 2nd SP | Kevin Gausman | Tor | 6 | Bos(3) Cle(3) | This Saturday vs Cle (Gavin Williams) |
| 3rd SP | Jose Berrios | Tor | 6 | Bos(3) Cle(3) | Last Pitched Thursday May 1st |
| 4th SP | Justin Verlander | SF | 6 | @SD(2) Col(4) | Last Pitched Thursday May 1st |
| 5th SP | Landen Roupp | SF | 6 | @SD(2) Col(4) | Last Pitched Wednesday April 30th |
| 6th SP | JP Sears | Oak | 7 | @Tex(4) @Mia(3) | This Sunday at Mia (Edward Cabrera) |
| 7th SP | Kyle Harrison | SF | 6 | @SD(2) Col(4) | Has Not Played Yet |
| 1st RP | Ryan Walker | SF | 6 | @SD(2) Col(4) | Last Pitched Saturday April 26th |
| 2nd RP | Robert Suarez | SD | 5 | SF(2) @Pit(3) | Last Pitched Wednesday April 30th |
| 3rd RP | Trevor Megill | Mil | 6 | @ChA(3) ChN(3) | Last Pitched Wednesday April 30th |
| 4th RP | David Bednar | Pit | 6 | ChN(3) SD(3) | Last Pitched Wednesday April 30th |
| 5th RP | Alexis Diaz | Cin | 8 | StL(5) Was(3) | Last Pitched Wednesday April 30th |
| 6th RP | Kyle Finnegan | Was | 7 | NYN(1) @Phi(3) @Cin(3) | Last Pitched Thursday May 1st |
| 7th RP | AJ Puk | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Thursday April 17th |
| 8th RP | Calvin Faucher | Mia | 6 | @LAD(3) Oak(3) | Last Pitched Monday April 28th |
| 9th RP | Tyler Holton | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Friday May 2nd |