| Position | Starters | Team | Games | Opponents |
| C | Logan O'Hoppe | LAA | 6 | @Sea(2) Det(4) |
| 1B | Jake Burger | Tex | 7 | Oak(4) Sea(3) |
| 2B | Jackson Holliday | Bal | 6 | NYA(3) KC(3) |
| SS | Ezequiel Tovar | Col | 7 | Atl(3) @SF(4) |
| 3B | Rafael Devers | Bos | 6 | @Tor(3) Min(3) |
| OF | Yordan Alvarez | Hou | 6 | Det(3) @ChA(3) |
| OF | Lawrence Butler | Oak | 7 | @Tex(4) @Mia(3) |
| OF | Kyle Tucker | ChN | 6 | @Pit(3) @Mil(3) |
| DH (1B) | Vinnie Pasquantino | KC | 6 | @TB(3) @Bal(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Patrick Bailey | SF | 6 | @SD(2) Col(4) |
| 1B | Tyler Soderstrom | Oak | 7 | @Tex(4) @Mia(3) |
| 2B | Tyler Fitzgerald | SF | 6 | @SD(2) Col(4) |
| SS | Jeremy Pena | Hou | 6 | Det(3) @ChA(3) |
| 3B | Maikel Garcia | KC | 6 | @TB(3) @Bal(3) |
| OF | Alec Burleson | StL | 8 | @Cin(5) NYN(3) |
| Position | Bench | Team | Games | Opponents |
| C | Ryan Jeffers | Min | 7 | @Cle(4) @Bos(3) |
| 1B | Nolan Schanuel | LAA | 6 | @Sea(2) Det(4) |
| 2B | Brendan Donovan | StL | 8 | @Cin(5) NYN(3) |
| 3B | Josh Smith | Tex | 7 | Oak(4) Sea(3) |
| OF | Masataka Yoshida | Bos | 6 | @Tor(3) Min(3) |
| Pitching Staff Alignment |
| 10 Starts, 0 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Blake Snell | LAD | 6 | Mia(3) @Atl(3) | Last Pitched Wednesday April 2nd |
| 2nd SP | Framber Valdez | Hou | 6 | Det(3) @ChA(3) | Last Pitched Friday May 2nd |
| 3rd SP | Pablo Lopez | Min | 7 | @Cle(4) @Bos(3) | Last Pitched Wednesday April 30th |
| 4th SP | Jack Flaherty | Det | 7 | @Hou(3) @LAA(4) | This Saturday at LAA (Kyle Hendricks) |
| 5th SP | Clarke Schmidt | NYA | 6 | @Bal(3) TB(3) | This Saturday vs TB (Zack Littell) |
| 6th SP | José Soriano | LAA | 6 | @Sea(2) Det(4) | Last Pitched Friday May 2nd |
| 7th SP | Mick Abel | Phi | 6 | Was(3) Ari(3) | Has Not Played Yet |
| 1st RP | Tanner Scott | LAD | 6 | Mia(3) @Atl(3) | Last Pitched Friday May 2nd |
| 2nd RP | Lucas Erceg | KC | 6 | @TB(3) @Bal(3) | Last Pitched Wednesday April 30th |
| 3rd RP | Orion Kerkering | Phi | 6 | Was(3) Ari(3) | Last Pitched Thursday May 1st |
| 4th RP | Luke Jackson | Tex | 7 | Oak(4) Sea(3) | Last Pitched Wednesday April 30th |