| Position | Starters | Team | Games | Opponents |
| C | J.T. Realmuto | Phi | 6 | Was(3) Ari(3) |
| 1B | Christian Walker | Hou | 6 | Det(3) @ChA(3) |
| 2B | Ozzie Albies | Atl | 6 | @Col(3) LAD(3) |
| SS | Trea Turner | Phi | 6 | Was(3) Ari(3) |
| 3B | Nolan Arenado | StL | 8 | @Cin(5) NYN(3) |
| OF | Mike Trout | LAA | 6 | @Sea(2) Det(4) |
| OF | Christian Yelich | Mil | 6 | @ChA(3) ChN(3) |
| OF | Jarren Duran | Bos | 6 | @Tor(3) Min(3) |
| DH | Shohei Ohtani | LAD | 6 | Mia(3) @Atl(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Connor Wong | Bos | 6 | @Tor(3) Min(3) |
| 1B | Ryan Mountcastle | Bal | 6 | NYA(3) KC(3) |
| SS | Jose Caballero | TB | 6 | KC(3) @NYA(3) |
| OF | Nolan Jones | Cle | 7 | Min(4) @Tor(3) |
| DH (1B) | Colt Keith | Det | 7 | @Hou(3) @LAA(4) |
| Position | 2nd Backup | Team | Games | Opponents |
| SS | Bo Bichette | Tor | 6 | Bos(3) Cle(3) |
| OF | TJ Friedl | Cin | 8 | StL(5) Was(3) |
| DH (SS) | Trevor Story | Bos | 6 | @Tor(3) Min(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Garrett Crochet | Bos | 6 | @Tor(3) Min(3) | This Sunday vs Min (Chris Paddack) |
| 2nd SP | Tyler Glasnow | LAD | 6 | Mia(3) @Atl(3) | Last Pitched Sunday April 27th |
| 3rd SP | Spencer Schwellenbach | Atl | 6 | @Col(3) LAD(3) | This Saturday vs LAD (Roki Sasaki) |
| 4th SP | Shane McClanahan | TB | 6 | KC(3) @NYA(3) | Has Not Played Yet |
| 5th SP | Robbie Ray | SF | 6 | @SD(2) Col(4) | Last Pitched Friday May 2nd |
| 6th SP | Taj Bradley | TB | 6 | KC(3) @NYA(3) | This Sunday at NYA (Will Warren) |
| 7th SP | Spencer Arrighetti | Hou | 6 | Det(3) @ChA(3) | Last Pitched Saturday April 5th |
| 8th SP | Will Warren | NYA | 6 | @Bal(3) TB(3) | This Sunday vs TB (Taj Bradley) |
| 9th SP | Matt Boyd | ChN | 6 | @Pit(3) @Mil(3) | Last Pitched Wednesday April 30th |
| 10th SP | Cody Bradford | Tex | 7 | Oak(4) Sea(3) | Has Not Played Yet |
| 11th SP | Edwin Uceta | TB | 6 | KC(3) @NYA(3) | Last Pitched Sunday April 27th |
| 1st RP | Ryan Helsley | StL | 8 | @Cin(5) NYN(3) | Last Pitched Friday May 2nd |
| 2nd RP | Pete Fairbanks | TB | 6 | KC(3) @NYA(3) | Last Pitched Sunday April 27th |