| Position | Starters | Team | Games | Opponents |
| C | William Contreras | Mil | 6 | @ChA(3) ChN(3) |
| 1B | Yandy Diaz | TB | 6 | KC(3) @NYA(3) |
| 2B | Jonathan India | KC | 6 | @TB(3) @Bal(3) |
| SS | Dansby Swanson | ChN | 6 | @Pit(3) @Mil(3) |
| 3B | Matt Chapman | SF | 6 | @SD(2) Col(4) |
| OF | Randy Arozarena | Sea | 5 | LAA(2) @Tex(3) |
| OF | Anthony Santander | Tor | 6 | Bos(3) Cle(3) |
| OF | Taylor Ward | LAA | 6 | @Sea(2) Det(4) |
| DH (OF) | Kyle Schwarber | Phi | 6 | Was(3) Ari(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Bo Naylor | Cle | 7 | Min(4) @Tor(3) |
| 1B | Andrew Vaughn | ChA | 6 | Mil(3) Hou(3) |
| 2B | Jake Cronenworth | SD | 5 | SF(2) @Pit(3) |
| SS | J.P. Crawford | Sea | 5 | LAA(2) @Tex(3) |
| 3B | Ryan McMahon | Col | 7 | Atl(3) @SF(4) |
| OF | Jo Adell | LAA | 6 | @Sea(2) Det(4) |
| DH (1B) | Michael Busch | ChN | 6 | @Pit(3) @Mil(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| OF | Christopher Morel | TB | 6 | KC(3) @NYA(3) |
| Position | Bench | Team | Games | Opponents |
| 3B | Matt Vierling | Det | 7 | @Hou(3) @LAA(4) |
| Pitching Staff Alignment |
| 10 Starts, 0 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Tarik Skubal | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Friday May 2nd |
| 2nd SP | Justin Steele | ChN | 6 | @Pit(3) @Mil(3) | Last Pitched Monday April 7th |
| 3rd SP | Cristopher Sanchez | Phi | 6 | Was(3) Ari(3) | Last Pitched Wednesday April 30th |
| 4th SP | Tanner Houck | Bos | 6 | @Tor(3) Min(3) | Last Pitched Thursday May 1st |
| 5th SP | Chris Bassitt | Tor | 6 | Bos(3) Cle(3) | Last Pitched Friday May 2nd |
| 6th SP | Brady Singer | Cin | 8 | StL(5) Was(3) | Last Pitched Wednesday April 30th |
| 7th SP | Michael Wacha | KC | 6 | @TB(3) @Bal(3) | Last Pitched Friday May 2nd |
| 8th SP | Mitch Keller | Pit | 6 | ChN(3) SD(3) | Last Pitched Friday May 2nd |
| 9th SP | Jameson Taillon | ChN | 6 | @Pit(3) @Mil(3) | This Saturday at Mil (Jose Quintana) |
| 1st RP | Emmanuel Clase | Cle | 7 | Min(4) @Tor(3) | Last Pitched Wednesday April 30th |
| 2nd RP | Raisel Iglesias | Atl | 6 | @Col(3) LAD(3) | Last Pitched Monday April 28th |
| 3rd RP | Jason Foley | Det | 7 | @Hou(3) @LAA(4) | Has Not Played Yet |