| Position | Starters | Team | Games | Opponents |
| 1B | Vladimir Guerrero Jr. | Tor | 6 | Bos(3) Cle(3) |
| 2B | Ketel Marte | Ari | 6 | @NYN(3) @Phi(3) |
| SS | Francisco Lindor | NYN | 7 | @Was(1) Ari(3) @StL(3) |
| 3B | Mark Vientos | NYN | 7 | @Was(1) Ari(3) @StL(3) |
| OF | James Wood | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| OF | Heliot Ramos | SF | 6 | @SD(2) Col(4) |
| OF | Colton Cowser | Bal | 6 | NYA(3) KC(3) |
| DH (OF) | Byron Buxton | Min | 7 | @Cle(4) @Bos(3) |
| Position | 1st Backup | Team | Games | Opponents |
| 1B | Willson Contreras | StL | 8 | @Cin(5) NYN(3) |
| 2B | Zack Gelof | Oak | 7 | @Tex(4) @Mia(3) |
| OF | Ian Happ | ChN | 6 | @Pit(3) @Mil(3) |
| DH (OF) | Bryan Reynolds | Pit | 6 | ChN(3) SD(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| 1B | Jeimer Candelario | Cin | 8 | StL(5) Was(3) |
| 2B | Bryson Stott | Phi | 6 | Was(3) Ari(3) |
| OF | Matt Wallner | Min | 7 | @Cle(4) @Bos(3) |
| DH (OF) | Michael Conforto | LAD | 6 | Mia(3) @Atl(3) |
| Position | Bench | Team | Games | Opponents |
| 1B | Carlos Santana | Cle | 7 | Min(4) @Tor(3) |
| OF | Jordan Walker | StL | 8 | @Cin(5) NYN(3) |
| OF | Brandon Marsh | Phi | 6 | Was(3) Ari(3) |
| OF | Trevor Larnach | Min | 7 | @Cle(4) @Bos(3) |
| OF | Lane Thomas | Cle | 7 | Min(4) @Tor(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Dylan Cease | SD | 5 | SF(2) @Pit(3) | Last Pitched Friday May 2nd |
| 2nd SP | Aaron Nola | Phi | 6 | Was(3) Ari(3) | This Saturday vs Ari (Brandon Pfaadt) |
| 3rd SP | Reynaldo Lopez | Atl | 6 | @Col(3) LAD(3) | Last Pitched Friday March 28th |
| 4th SP | Yusei Kikuchi | LAA | 6 | @Sea(2) Det(4) | Last Pitched Thursday May 1st |
| 5th SP | Clay Holmes | NYN | 7 | @Was(1) Ari(3) @StL(3) | Last Pitched Friday May 2nd |
| 6th SP | Brandon Pfaadt | Ari | 6 | @NYN(3) @Phi(3) | This Saturday at Phi (Aaron Nola) |
| 7th SP | Nick Lodolo | Cin | 8 | StL(5) Was(3) | This Saturday vs Was (Trevor Williams) |
| 8th SP | Ryan Weathers | Mia | 6 | @LAD(3) Oak(3) | Has Not Played Yet |
| 1st RP | Jeff Hoffman | Tor | 6 | Bos(3) Cle(3) | Last Pitched Friday May 2nd |