| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Logan O'Hoppe | C | LAA | 25 | |
| Tyler Stephenson | C | Cin | 28 | |
| Nathaniel Lowe | 1B | Was | 29 | |
| Vinnie Pasquantino | 1B | KC | 27 | |
| Michael Toglia | 1B | Col | 26 | |
| Zack Gelof | 2B | Oak | 25 | March 23, 2025:15 Day IL |
| Gavin Lux | 2B (OF) | Cin | 27 | |
| Jordan Lawlar | SS | Ari | 22 | |
| Francisco Lindor | SS | NYN | 31 | |
| Jacob Wilson | SS | Oak | 23 | |
| Rafael Devers | 3B | Bos | 28 | |
| Ke'Bryan Hayes | 3B | Pit | 28 | |
| Jordan Westburg | 3B (2B) | Bal | 26 | April 28, 2025:10 Day IL |
| Jasson Dominguez | OF | NYA | 22 | |
| Brenton Doyle | OF | Col | 26 | |
| Tommy Edman | OF (2B) | LAD | 29 | |
| Teoscar Hernández | OF | LAD | 32 | |
| Heston Kjerstad | OF | Bal | 26 | |
| Ceddanne Rafaela | OF | Bos | 24 | |
| Seiya Suzuki | OF | ChN | 30 | |
| Daulton Varsho | OF | Tor | 28 | |
| Christian Yelich | OF | Mil | 33 | |
| Walker Buehler | SP | Bos | 30 | May 02, 2025:15 Day IL-Shoulder |
| Griffin Canning | SP | NYN | 28 | |
| Zac Gallen | SP | Ari | 29 | |
| Clay Holmes | SP | NYN | 32 | |
| Mitch Keller | SP | Pit | 29 | |
| Michael King | SP | SD | 29 | |
| Eduardo Rodriguez | SP | Ari | 32 | |
| Michael Wacha | SP | KC | 33 | |
| Luke Weaver | SP (RP) | NYA | 31 | |
| Bryan Woo | SP | Sea | 25 | |
| Kyle Finnegan | RP | Was | 33 | |
| Robert Suarez | RP | SD | 34 |