| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Jonah Heim | C | Tex | 29 | |
| J.T. Realmuto | C | Phi | 34 | |
| Jac Caglianone | 1B | KC | 22 | |
| Freddie Freeman | 1B | LAD | 35 | |
| Nick Kurtz | 1B | Oak | 22 | |
| Jose Altuve | 2B (OF) | Hou | 34 | |
| Travis Bazzana | 2B | Cle | 22 | |
| J.P. Crawford | SS | Sea | 30 | |
| Leodalis De Vries | SS | SD | 18 | |
| Masyn Winn | SS | StL | 23 | |
| Manny Machado | 3B | SD | 32 | |
| Noelvi Marte | 3B | Cin | 23 | |
| Cam Smith | 3B (OF) | Hou | 22 | |
| Ronald Acuna Jr. | OF | Atl | 27 | March 25, 2025:10 Day IL |
| Nick Castellanos | OF | Phi | 33 | |
| Tommy Edman | OF (2B) | LAD | 29 | |
| Walker Jenkins | OF | Min | 20 | |
| Andy Pages | OF | LAD | 24 | |
| Mike Yastrzemski | OF | SF | 34 | |
| Christian Yelich | OF | Mil | 33 | |
| Shane Bieber | SP | Cle | 29 | March 27, 2025:15 Day IL |
| Jacob deGrom | SP | Tex | 36 | |
| Zach Eflin | SP | Bal | 31 | April 09, 2025:15 Day IL |
| Sonny Gray | SP | StL | 35 | |
| Ryan Gusto | SP (RP) | Hou | N/A | |
| Cade Horton | SP | ChN | 23 | |
| George Kirby | SP | Sea | 27 | March 27, 2025:15 Day IL |
| Pablo Lopez | SP | Min | 29 | |
| Ranger Suarez | SP | Phi | 29 | March 23, 2025:15 Day IL |
| Jameson Taillon | SP | ChN | 33 | |
| Hayden Wesneski | SP | Hou | 27 | |
| Raisel Iglesias | RP | Atl | 35 | |
| Justin Martinez | RP | Ari | 23 | May 01, 2025:15 Day IL |
| Mason Miller | RP | Oak | 26 |