| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Francisco Álvarez | C | NYN | 23 | |
| Alejandro Kirk | C | Tor | 26 | |
| Shea Langeliers | C | Oak | 27 | |
| Jake Burger | 1B | Tex | 29 | |
| Bryce Harper | 1B | Phi | 33 | |
| Jake Cronenworth | 2B (1B,SS) | SD | 31 | |
| Christian Moore | 2B | LAA | 23 | |
| Marcus Semien | 2B | Tex | 35 | August 23, 2025:60 Day IL |
| Mookie Betts | SS | LAD | 33 | |
| Zach Neto | SS | LAA | 24 | September 16, 2025:10 Day IL |
| Corey Seager | SS | Tex | 31 | August 29, 2025:10 Day IL |
| Ezequiel Tovar | SS | Col | 24 | |
| Alec Bohm | 3B (1B) | Phi | 29 | |
| Royce Lewis | 3B | Min | 26 | |
| Ryan McMahon | 3B | NYA | 30 | |
| Jo Adell | OF | LAA | 26 | |
| Jordan Beck | OF | Col | 24 | |
| Riley Greene | OF | Det | 25 | |
| Aaron Judge | OF | NYA | 33 | |
| Andy Pages | OF | LAD | 24 | |
| Luis Robert Jr. | OF | ChA | 28 | August 27, 2025:10 Day IL |
| Sandy Alcantara | SP | Mia | 30 | |
| Spencer Arrighetti | SP | Hou | N/A | September 03, 2025:15 Day IL |
| Brayan Bello | SP | Bos | 26 | |
| Kris Bubic | SP | KC | 28 | July 27, 2025:15 Day IL |
| MacKenzie Gore | SP | Was | 26 | September 23, 2025:15 Day IL |
| Casey Mize | SP | Det | 28 | |
| Max Scherzer | SP | Tor | 41 | |
| Ranger Suarez | SP | Phi | 30 | |
| Hurston Waldrep | SP | Atl | N/A | |
| Gavin Williams | SP | Cle | 26 | |
| Felix Bautista | RP | Bal | 30 | July 24, 2025:60 Day IL |
| Jhoan Duran | RP | Phi | 27 | |
| Raisel Iglesias | RP | Atl | 35 |