| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Francisco Álvarez | C | NYN | 23 | |
| Shea Langeliers | C | Oak | 27 | |
| Bryce Harper | 1B | Phi | 32 | |
| Michael Toglia | 1B | Col | 26 | |
| Jake Cronenworth | 2B | SD | 31 | April 11, 2025:10 Day IL |
| Marcus Semien | 2B | Tex | 34 | |
| Gabriel Arias | SS (2B,3B) | Cle | 25 | |
| Mookie Betts | SS | LAD | 32 | |
| Zach Neto | SS | LAA | 24 | |
| Corey Seager | SS | Tex | 31 | April 23, 2025:10 Day IL |
| Ezequiel Tovar | SS | Col | 23 | April 19, 2025:10 Day IL |
| Alec Bohm | 3B | Phi | 28 | |
| Caleb Durbin | 3B | Mil | 25 | |
| Royce Lewis | 3B | Min | 25 | March 27, 2025:15 Day IL-Ab strain |
| Ryan McMahon | 3B | Col | 30 | |
| Dylan Moore | 3B (2B,OF) | Sea | 32 | April 29, 2025:10 Day IL |
| Jordan Beck | OF | Col | 24 | |
| JJ Bleday | OF | Oak | 27 | |
| Riley Greene | OF | Det | 24 | |
| Aaron Judge | OF | NYA | 33 | |
| Andy Pages | OF | LAD | 24 | |
| Luis Robert Jr. | OF | ChA | 27 | |
| Kris Bubic | SP | KC | 27 | |
| Andrew Heaney | SP | Pit | 33 | |
| Tanner Houck | SP | Bos | 28 | |
| Tyler Mahle | SP | Tex | 30 | |
| Casey Mize | SP | Det | 28 | |
| Reese Olson | SP | Det | 25 | |
| Clarke Schmidt | SP | NYA | 29 | |
| Ranger Suarez | SP | Phi | 29 | March 23, 2025:15 Day IL |
| Gavin Williams | SP | Cle | 25 | |
| Jhoan Duran | RP | Min | 27 | |
| Raisel Iglesias | RP | Atl | 35 | |
| Devin Williams | RP | NYA | 30 |