| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Willson Contreras | C (DH) | ChN | 28 | |
| Pedro Severino | C (DH) | Bal | 27 | |
| Trey Mancini | 1B | Bal | 28 | June 28, 2020:15 Day IL-10/13 concussion |
| Dan Murphy | 1B (DH) | Col | 35 | |
| Rowdy Tellez | 1B (DH) | Tor | 25 | September 09, 2020:10 Day IL-Right knee strain |
| Jean Segura | 2B (3B,SS) | Phi | 30 | |
| Kolten Wong | 2B | StL | 30 | |
| Javier Baez | SS | ChN | 27 | |
| Kevin Newman | SS (2B) | Pit | 27 | September 20, 2020:10 Day IL-Left knee contusion |
| Nolan Arenado | 3B | Col | 29 | September 20, 2020:10 Day IL-Left shoulder bone bruise |
| Matt Carpenter | 3B (1B,DH) | StL | 34 | |
| Dylan Moore | 3B (1B,2B,SS,OF) | Sea | 28 | September 22, 2020:7 Day IL-Concussion |
| Andrew Benintendi | OF | Bos | 26 | August 12, 2020:10 Day IL-Strained right ribcage |
| Michael Brantley | OF (DH) | Hou | 33 | |
| Jasson Dominguez | OF | NYA | 17 | |
| JaCoby Jones | OF | Det | 28 | September 02, 2020:10 Day IL-Fractured left hand |
| Max Kepler | OF | Min | 27 | |
| Kyle Lewis | OF | Sea | 25 | |
| Franmil Reyes | OF (DH) | Cle | 25 | |
| Edwin Encarnacion | DH | ChA | 37 | |
| Ian Anderson | SP | Atl | 22 | |
| Aaron Civale | SP | Cle | 25 | |
| Mike Clevinger | SP | SD | 29 | |
| Zach Davies | SP | SD | 27 | |
| Marco Gonzales | SP | Sea | 28 | |
| Cole Hamels | SP | Atl | 36 | September 21, 2020:10 Day IL-Left shoulder fatigue |
| Triston McKenzie | SP (RP) | Cle | 23 | |
| Rafael Montero | SP (RP) | Tex | 29 | |
| Spencer Turnbull | SP | Det | 28 | |
| Justin Verlander | SP | Hou | 37 | July 25, 2020:15 Day IL-Abdomen |
| Taijuan Walker | SP | Tor | 28 | |
| Forrest Whitley | SP | Hou | 23 | |
| Randy Dobnak | RP (SP) | Min | 25 | |
| Roberto Osuna | RP | Hou | 25 | August 02, 2020:10 Day IL-Right elbow soreness |