| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Francisco Álvarez | C | NYN | 23 | |
| Shea Langeliers | C | Oak | 27 | |
| Michael Busch | 1B | ChN | 27 | |
| Yandy Diaz | 1B | TB | 33 | |
| Matt Olson | 1B | Atl | 31 | |
| Tyler Fitzgerald | 2B | SF | 27 | May 01, 2025:10 Day IL |
| Nolan Gorman | 2B | StL | 24 | |
| Gleyber Torres | 2B | Det | 28 | |
| Xander Bogaerts | SS | SD | 32 | |
| Elly De La Cruz | SS | Cin | 23 | |
| Rafael Devers | 3B | Bos | 28 | |
| Ke'Bryan Hayes | 3B | Pit | 28 | |
| Josh Smith | 3B (SS) | Tex | 27 | |
| Nick Castellanos | OF | Phi | 33 | |
| Brenton Doyle | OF | Col | 26 | |
| Jarren Duran | OF | Bos | 28 | |
| Adolis Garcia | OF | Tex | 32 | |
| Ceddanne Rafaela | OF | Bos | 24 | |
| Jesus Sanchez | OF | Mia | 27 | |
| Mike Trout | OF | LAA | 33 | May 02, 2025:10 Day IL |
| Shane Bieber | SP | Cle | 29 | March 27, 2025:15 Day IL |
| Hunter Brown | SP | Hou | 26 | |
| Pat Corbin | SP | Tex | 35 | |
| Zach Eflin | SP | Bal | 31 | April 09, 2025:15 Day IL |
| Seth Lugo | SP | KC | 35 | |
| Andre Pallante | SP | StL | 26 | |
| Jose Quintana | SP | Mil | 36 | |
| Chris Sale | SP | Atl | 36 | |
| Max Scherzer | SP | Tor | 40 | March 30, 2025:15 Day IL-Thumb |
| Luke Weaver | SP (RP) | NYA | 31 | |
| Brandon Woodruff | SP | Mil | 32 | March 27, 2025:15 Day IL |
| Emilio Pagan | RP | Cin | 33 | |
| Robert Suarez | RP | SD | 34 | |
| Devin Williams | RP | NYA | 30 |