| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Jason Castro | C | SD | 33 | |
| Francisco Mejia | C | SD | 25 | |
| Pedro Severino | C (DH) | Bal | 27 | |
| Jose Abreu | 1B (DH) | ChA | 33 | |
| Dan Murphy | 1B (DH) | Col | 35 | |
| Jonathan Schoop | 2B | Det | 29 | September 13, 2020:10 Day IL-Sprained right wrist |
| Jean Segura | 2B (3B,SS) | Phi | 30 | |
| Donovan Solano | 2B (3B) | SF | 32 | |
| Carlos Correa | SS | Hou | 26 | |
| Kevin Newman | SS (2B) | Pit | 27 | September 20, 2020:10 Day IL-Left knee contusion |
| Asdrubal Cabrera | 3B (1B,DH) | Was | 35 | |
| Josh Donaldson | 3B | Min | 34 | |
| Dylan Moore | 3B (1B,2B,SS,OF) | Sea | 28 | September 22, 2020:7 Day IL-Concussion |
| Jose Ramirez | 3B | Cle | 28 | |
| Jo Adell | OF | LAA | 21 | |
| Dylan Carlson | OF | StL | 22 | |
| Jasson Dominguez | OF | NYA | 17 | |
| Hunter Dozier | OF (1B) | KC | 29 | |
| Sam Hilliard | OF | Col | 26 | |
| JaCoby Jones | OF | Det | 28 | September 02, 2020:10 Day IL-Fractured left hand |
| Tommy Pham | OF (DH) | SD | 32 | |
| Domingo Santana | OF | Cle | 28 | |
| Nelson Cruz | DH | Min | 40 | |
| Jose Berrios | SP | Min | 26 | |
| Dylan Cease | SP | ChA | 24 | |
| Zach Davies | SP | SD | 27 | |
| Lucas Giolito | SP | ChA | 26 | |
| Tony Gonsolin | SP | LAD | 26 | |
| Frankie Montas | SP | Oak | 27 | |
| Rafael Montero | SP (RP) | Tex | 29 | |
| Sixto Sánchez | SP | Mia | 22 | |
| Adam Wainwright | SP | StL | 39 | |
| Forrest Whitley | SP | Hou | 23 | |
| Oliver Drake | RP | TB | 33 |