| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Edgar Quero | C | ChA | 22 | |
| Adley Rutschman | C | Bal | 27 | |
| Will Smith | C | LAD | 30 | |
| Luis Arraez | 1B | SD | 28 | |
| Andrew Vaughn | 1B | ChA | 27 | |
| Willi Castro | 2B (SS,3B) | Min | 28 | April 24, 2025:10 Day IL |
| Nico Hoerner | 2B | ChN | 27 | |
| CJ Abrams | SS | Was | 24 | |
| Jose Caballero | SS (3B,OF) | TB | 28 | |
| Manny Machado | 3B | SD | 32 | |
| Dylan Moore | 3B (2B,OF) | Sea | 32 | April 29, 2025:10 Day IL |
| Randy Arozarena | OF | Sea | 30 | |
| Colton Cowser | OF | Bal | 25 | March 31, 2025:60 Day IL-Left thumb fracture |
| Pete Crow-Armstrong | OF | ChN | 23 | |
| Heston Kjerstad | OF | Bal | 26 | |
| Josh Lowe | OF | TB | 27 | March 29, 2025:10 Day IL |
| Parker Meadows | OF | Det | 25 | March 24, 2025:60 Day IL |
| Kameron Misner | OF | TB | N/A | |
| Victor Scott | OF | StL | 24 | |
| Chris Bassitt | SP | Tor | 36 | |
| Ben Brown | SP | ChN | 25 | |
| Dylan Cease | SP | SD | 29 | |
| Nestor Cortes Jr. | SP | Mil | 30 | April 06, 2025:60 Day IL-Left elbow flexor strain |
| Sonny Gray | SP | StL | 35 | |
| Hunter Greene | SP | Cin | 25 | |
| Bailey Ober | SP | Min | 29 | |
| Ryan Pepiot | SP | TB | 27 | |
| Nick Pivetta | SP | SD | 32 | |
| Grayson Rodriguez | SP | Bal | 25 | March 27, 2025:60 Day IL |
| Blake Snell | SP | LAD | 32 | April 06, 2025:15 Day IL-Ab strain |
| Justin Steele | SP | ChN | 29 | April 09, 2025:60 Day IL |
| Raisel Iglesias | RP | Atl | 35 | |
| Kenley Jansen | RP | LAA | 37 | |
| Will Vest | RP | Det | 29 |