| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Joey Bart | C | Pit | 28 | |
| Logan O'Hoppe | C | LAA | 25 | |
| Vinnie Pasquantino | 1B | KC | 27 | |
| Christian Walker | 1B | Hou | 34 | |
| Wilmer Flores | 2B | SF | 33 | |
| Gavin Lux | 2B (OF) | Cin | 27 | |
| Ketel Marte | 2B | Ari | 31 | April 05, 2025:10 Day IL |
| Gabriel Arias | SS (2B) | Cle | 25 | |
| J.P. Crawford | SS | Sea | 30 | |
| Corey Seager | SS | Tex | 31 | April 23, 2025:10 Day IL |
| Caleb Durbin | 3B | Mil | 25 | |
| Max Muncy | 3B | LAD | 34 | |
| Jordan Westburg | 3B (2B) | Bal | 26 | April 28, 2025:10 Day IL |
| JJ Bleday | OF | Oak | 27 | |
| Byron Buxton | OF | Min | 31 | |
| Austin Hays | OF | Cin | 29 | |
| Jung Hoo Lee | OF | SF | 26 | |
| Tyler O'Neill | OF | Bal | 29 | April 26, 2025:10 Day IL |
| Luis Robert Jr. | OF | ChA | 27 | |
| Kyle Stowers | OF | Mia | 27 | |
| Andrew Abbott | SP | Cin | 25 | |
| Sandy Alcantara | SP | Mia | 29 | |
| Brayan Bello | SP | Bos | 25 | |
| Griffin Canning | SP | NYN | 28 | |
| Nathan Eovaldi | SP | Tex | 35 | |
| Sean Manaea | SP | NYN | 33 | March 27, 2025:60 Day IL |
| Aaron Nola | SP | Phi | 31 | |
| Mitchell Parker | SP | Was | 25 | |
| Drew Rasmussen | SP | TB | 29 | |
| Luis Severino | SP | Oak | 31 | |
| Tarik Skubal | SP | Det | 28 | |
| Josh Hader | RP | Hou | 31 | |
| Justin Martinez | RP | Ari | 23 | May 01, 2025:15 Day IL |
| Ryan Pressly | RP | ChN | 36 |