| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Logan O'Hoppe | C | LAA | 25 | |
| Willson Contreras | 1B | StL | 32 | |
| Kyle Manzardo | 1B | Cle | 24 | |
| Vinnie Pasquantino | 1B | KC | 27 | |
| Tyler Fitzgerald | 2B | SF | 27 | May 01, 2025:10 Day IL |
| Christian Moore | 2B | LAA | 22 | |
| Bo Bichette | SS | Tor | 27 | |
| Jordan Lawlar | SS | Ari | 22 | |
| Jeremy Pena | SS | Hou | 27 | |
| Sebastian Walcott | SS | Tex | 19 | |
| Junior Caminero | 3B | TB | 21 | |
| Matt Shaw | 3B | ChN | 23 | |
| Mark Vientos | 3B | NYN | 25 | |
| Kerry Carpenter | OF | Det | 27 | |
| Evan Carter | OF | Tex | 22 | |
| Dylan Crews | OF | Was | 23 | |
| Luis Robert Jr. | OF | ChA | 27 | |
| Jorge Soler | OF | LAA | 32 | |
| Zac Veen | OF | Col | N/A | |
| Mike Yastrzemski | OF | SF | 34 | |
| Jose Berrios | SP | Tor | 30 | |
| Walker Buehler | SP | Bos | 30 | |
| Gerrit Cole | SP | NYA | 34 | March 22, 2025:60 Day IL |
| Bowden Francis | SP | Tor | 29 | |
| Logan Gilbert | SP | Sea | 27 | April 26, 2025:15 Day IL |
| Tyler Mahle | SP | Tex | 30 | |
| Zebby Matthews | SP | Min | N/A | |
| Max Meyer | SP | Mia | 26 | |
| Cristopher Sanchez | SP | Phi | 28 | |
| Max Scherzer | SP | Tor | 40 | March 30, 2025:15 Day IL-Thumb |
| Spencer Schwellenbach | SP | Atl | 24 | |
| José Soriano | SP | LAA | 26 | |
| Camilo Doval | RP | SF | 27 | |
| Ryan Walker | RP | SF | N/A |