| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Yainer Diaz | C | Hou | 26 | |
| Ivan Herrera | C | StL | 25 | June 20, 2025:10 Day IL |
| Sean Murphy | C | Atl | 30 | |
| Luis Arraez | 1B | SD | 28 | |
| Triston Casas | 1B | Bos | 25 | May 03, 2025:60 Day IL |
| Travis Bazzana | 2B | Cle | 22 | |
| Andrés Gimenez | 2B | Tor | 26 | July 06, 2025:10 Day IL |
| Nico Hoerner | 2B | ChN | 28 | |
| Matt McLain | 2B | Cin | 25 | |
| Orlando Arcia | SS (1B,2B,3B) | Col | 30 | |
| Xander Bogaerts | SS | SD | 32 | |
| Corey Seager | SS | Tex | 31 | |
| Ke'Bryan Hayes | 3B | Pit | 28 | |
| Royce Lewis | 3B | Min | 26 | |
| Josh Smith | 3B (1B,SS,OF) | Tex | 27 | |
| Alec Burleson | OF (1B) | StL | 26 | |
| Max Clark | OF | Det | 20 | |
| Michael Conforto | OF | LAD | 32 | |
| Pete Crow-Armstrong | OF | ChN | 23 | |
| Steven Kwan | OF | Cle | 27 | |
| Taylor Ward | OF | LAA | 31 | |
| Ben Brown | SP | ChN | 25 | |
| Luis Castillo | SP | Sea | 32 | |
| Dylan Cease | SP | SD | 29 | |
| Sonny Gray | SP | StL | 35 | |
| Tanner Houck | SP | Bos | 29 | May 14, 2025:15 Day IL |
| Michael King | SP | SD | 30 | May 25, 2025:60 Day IL |
| Charlie Morton | SP (RP) | Bal | 41 | |
| Blake Snell | SP | LAD | 32 | April 06, 2025:60 Day IL-Ab strain |
| Spencer Strider | SP | Atl | 26 | |
| Logan Webb | SP | SF | 28 | |
| Jhoan Duran | RP | Min | 27 | |
| Jeff Hoffman | RP | Tor | 32 | |
| Kirby Yates | RP | LAD | 38 |