| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Salvador Perez | C (C,1B) | KC | 34 | |
| J.T. Realmuto | C | Phi | 34 | |
| Luis Arraez | 1B | SD | 28 | |
| Michael Busch | 1B | ChN | 27 | |
| Jeimer Candelario | 1B (3B) | Cin | 31 | April 30, 2025:10 Day IL |
| Willi Castro | 2B (SS,3B) | Min | 28 | April 24, 2025:10 Day IL |
| Tyler Fitzgerald | 2B | SF | 27 | May 01, 2025:10 Day IL |
| Gleyber Torres | 2B | Det | 28 | |
| Xander Bogaerts | SS | SD | 32 | |
| Eugenio Suarez | 3B | Ari | 33 | |
| Jordan Westburg | 3B (2B) | Bal | 26 | April 28, 2025:10 Day IL |
| Wilyer Abreu | OF | Bos | 25 | |
| Andrew Benintendi | OF | ChA | 30 | |
| Byron Buxton | OF | Min | 31 | |
| Oneil Cruz | OF | Pit | 26 | |
| Steven Kwan | OF | Cle | 27 | |
| George Springer | OF | Tor | 35 | |
| Giancarlo Stanton | OF | NYA | 35 | March 26, 2025:60 Day IL |
| Seiya Suzuki | OF | ChN | 30 | |
| Ben Brown | SP | ChN | 25 | |
| Jonathan Cannon | SP | ChA | N/A | |
| Nestor Cortes Jr. | SP | Mil | 30 | April 06, 2025:60 Day IL-Left elbow flexor strain |
| Yu Darvish | SP | SD | 38 | March 27, 2025:15 Day IL |
| Hunter Dobbins | SP | Bos | N/A | |
| Erick Fedde | SP | StL | 32 | |
| Sonny Gray | SP | StL | 35 | |
| Cade Horton | SP | ChN | 23 | |
| Shota Imanaga | SP | ChN | 31 | |
| Jack Leiter | SP | Tex | N/A | |
| Carlos Rodon | SP | NYA | 32 | |
| Luis Severino | SP | Oak | 31 | |
| Blake Snell | SP | LAD | 32 | April 06, 2025:15 Day IL-Ab strain |
| Edwin Diaz | RP | NYN | 31 | |
| Ryan Pressly | RP | ChN | 36 |