| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Tyler Heineman | C | Tor | 33 | |
| Shea Langeliers | C | Oak | 27 | |
| Triston Casas | 1B | Bos | 25 | |
| Bryce Harper | 1B | Phi | 32 | |
| Tyler Soderstrom | 1B (OF) | Oak | 23 | |
| Eric Wagaman | 1B (OF) | Mia | N/A | |
| Jazz Chisholm Jr. | 2B | NYA | 27 | May 02, 2025:15 Day IL-Oblique |
| Jonathan India | 2B (3B,OF) | KC | 28 | |
| Xavier Edwards | SS | Mia | 25 | |
| Kyren Paris | SS (2B,OF) | LAA | 23 | |
| Anthony Volpe | SS | NYA | 24 | |
| Masyn Winn | SS | StL | 23 | |
| Connor Norby | 3B | Mia | 24 | |
| Mark Vientos | 3B | NYN | 25 | |
| Jackson Chourio | OF | Mil | 21 | |
| Trent Grisham | OF | NYA | 28 | |
| Kameron Misner | OF | TB | N/A | |
| Ceddanne Rafaela | OF | Bos | 24 | |
| Heliot Ramos | OF | SF | 25 | |
| Tim Tawa | OF (2B) | Ari | N/A | |
| Jordan Walker | OF | StL | 22 | |
| Walker Buehler | SP | Bos | 30 | May 02, 2025:15 Day IL-Shoulder |
| Gerrit Cole | SP | NYA | 34 | March 22, 2025:60 Day IL |
| Garrett Crochet | SP | Bos | 25 | |
| Clay Holmes | SP | NYN | 32 | |
| Matthew Liberatore | SP | StL | 25 | |
| Pablo Lopez | SP | Min | 29 | |
| Dustin May | SP | LAD | 27 | |
| Bryce Miller | SP | Sea | 26 | |
| Spencer Schwellenbach | SP | Atl | 24 | |
| Blake Snell | SP | LAD | 32 | April 06, 2025:15 Day IL-Ab strain |
| Spencer Strider | SP | Atl | 26 | April 21, 2025:15 Day IL |
| Josh Hader | RP | Hou | 31 | |
| Devin Williams | RP | NYA | 30 |