| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Ryan Jeffers | C | Min | 27 | |
| Salvador Perez | C (C,1B) | KC | 34 | |
| Nathaniel Lowe | 1B | Was | 29 | |
| Nolan Schanuel | 1B | LAA | 23 | |
| Christian Walker | 1B | Hou | 34 | |
| Jake Cronenworth | 2B | SD | 31 | April 11, 2025:10 Day IL |
| Tyler Fitzgerald | 2B | SF | 27 | May 01, 2025:10 Day IL |
| Luis Garcia | 2B | Was | 24 | |
| Gavin Lux | 2B (OF) | Cin | 27 | |
| Gabriel Arias | SS (2B,3B) | Cle | 25 | |
| Geraldo Perdomo | SS | Ari | 25 | |
| Matt Chapman | 3B | SF | 32 | |
| Max Muncy | 3B | LAD | 34 | |
| Josh Smith | 3B (SS) | Tex | 27 | |
| Jo Adell | OF | LAA | 26 | |
| Yordan Alvarez | OF | Hou | 27 | |
| Teoscar Hernández | OF | LAD | 32 | |
| Aaron Judge | OF | NYA | 33 | |
| Max Kepler | OF | Phi | 32 | |
| Brandon Marsh | OF | Phi | 27 | April 20, 2025:10 Day IL |
| Anthony Santander | OF | Tor | 30 | |
| Christian Yelich | OF | Mil | 33 | |
| Tyler Anderson | SP | LAA | 35 | |
| Shane Baz | SP | TB | 25 | |
| Richard Fitts | SP | Bos | N/A | April 13, 2025:15 Day IL |
| Mitch Keller | SP | Pit | 29 | |
| Ben Lively | SP | Cle | 33 | |
| Mike Lorenzen | SP | KC | 33 | |
| Seth Lugo | SP | KC | 35 | |
| Ryan Pepiot | SP | TB | 27 | |
| Luis Severino | SP | Oak | 31 | |
| Emmanuel Clase | RP | Cle | 27 | |
| Camilo Doval | RP | SF | 27 | |
| Kyle Finnegan | RP | Was | 33 |