| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Sean Murphy | C | Atl | 30 | |
| Logan O'Hoppe | C | LAA | 25 | |
| Agustin Ramirez | C | Mia | 23 | |
| Matt Mervis | 1B | Mia | 27 | |
| Matt Olson | 1B | Atl | 31 | |
| Michael Toglia | 1B | Col | 26 | |
| Romy Gonzalez | 2B (1B) | Bos | 28 | |
| Jackson Holliday | 2B (SS) | Bal | 21 | |
| Jeff McNeil | 2B | NYN | 33 | |
| Jacob Wilson | SS | Oak | 23 | |
| Bobby Witt Jr. | SS | KC | 24 | |
| Rafael Devers | 3B | Bos | 28 | |
| Caleb Durbin | 3B | Mil | 25 | |
| Matt Shaw | 3B | ChN | 23 | |
| Randy Arozarena | OF | Sea | 30 | |
| Jordan Beck | OF | Col | 24 | |
| Jasson Dominguez | OF | NYA | 22 | |
| Jarren Duran | OF | Bos | 28 | |
| Steven Kwan | OF | Cle | 27 | |
| Victor Scott | OF | StL | 24 | |
| George Springer | OF | Tor | 35 | |
| Chris Bassitt | SP | Tor | 36 | |
| Corbin Burnes | SP | Ari | 30 | |
| Dylan Cease | SP | SD | 29 | |
| Bubba Chandler | SP | Pit | N/A | |
| Tyler Glasnow | SP | LAD | 31 | April 29, 2025:15 Day IL |
| Shane McClanahan | SP | TB | 28 | March 26, 2025:60 Day IL-Ab strain |
| Eury Perez | SP | Mia | 22 | February 20, 2025:60 Day IL |
| Robbie Ray | SP | SF | 33 | |
| Grayson Rodriguez | SP | Bal | 25 | March 27, 2025:60 Day IL |
| Jeffrey Springs | SP | Oak | 32 | |
| José Alvarado | RP | Phi | 29 | |
| Felix Bautista | RP | Bal | 29 | |
| Aroldis Chapman | RP | Bos | 37 |