| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Jonah Heim | C | Tex | 29 | |
| Cal Raleigh | C | Sea | 28 | |
| Tyler Stephenson | C | Cin | 28 | |
| Michael Busch | 1B | ChN | 27 | |
| Rhys Hoskins | 1B | Mil | 32 | |
| Marcus Semien | 2B | Tex | 34 | |
| Brice Turang | 2B | Mil | 25 | |
| Carlos Correa | SS | Min | 30 | |
| Isiah Kiner-Falefa | SS | Pit | 30 | |
| Brooks Baldwin | 3B (2B,SS,OF) | ChA | N/A | |
| Eugenio Suarez | 3B | Ari | 33 | |
| Matt Vierling | 3B | Det | 28 | March 27, 2025:10 Day IL |
| JJ Bleday | OF | Oak | 27 | |
| Adolis Garcia | OF | Tex | 32 | |
| Ian Happ | OF | ChN | 30 | |
| Andrew McCutchen | OF | Pit | 38 | |
| Cedric Mullins II | OF | Bal | 30 | |
| Brandon Nimmo | OF | NYN | 32 | |
| Luke Raley | OF (1B) | Sea | 30 | May 01, 2025:15 Day IL-Ab strain |
| Daulton Varsho | OF | Tor | 28 | |
| Marcell Ozuna | DH | Atl | 34 | |
| Hayden Birdsong | SP (RP) | SF | N/A | |
| Ronel Blanco | SP | Hou | 31 | |
| Griffin Canning | SP | NYN | 28 | |
| Nestor Cortes Jr. | SP | Mil | 30 | April 06, 2025:60 Day IL-Left elbow flexor strain |
| Grant Holmes | SP | Atl | N/A | |
| David Peterson | SP | NYN | 29 | |
| Drew Rasmussen | SP | TB | 29 | |
| JP Sears | SP | Oak | 29 | |
| Ranger Suarez | SP | Phi | 29 | March 23, 2025:15 Day IL |
| Logan Webb | SP | SF | 28 | |
| Hayden Wesneski | SP | Hou | 27 | |
| Jhoan Duran | RP | Min | 27 | |
| Robert Suarez | RP | SD | 34 |