| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Ivan Herrera | C | StL | 24 | April 07, 2025:15 Day IL-Knee |
| Carson Kelly | C | ChN | 30 | |
| Pedro Pages | C | StL | 26 | |
| Christian Encarnacion-Strand | 1B | Cin | 25 | April 17, 2025:10 Day IL |
| Freddie Freeman | 1B | LAD | 35 | |
| Ryan O'Hearn | 1B (OF) | Bal | 31 | |
| Ben Rice | 1B | NYA | 26 | |
| Zack Gelof | 2B | Oak | 25 | March 23, 2025:15 Day IL |
| Bryson Stott | 2B | Phi | 27 | |
| CJ Abrams | SS | Was | 24 | |
| Adael Amador | SS (2B) | Col | N/A | |
| Jeremy Pena | SS | Hou | 27 | |
| Manny Machado | 3B | SD | 32 | |
| Noelvi Marte | 3B | Cin | 23 | |
| Byron Buxton | OF | Min | 31 | |
| Tommy Edman | OF (2B) | LAD | 29 | |
| Michael Harris II | OF | Atl | 24 | |
| Tyler O'Neill | OF | Bal | 29 | April 26, 2025:10 Day IL |
| Chandler Simpson | OF | TB | 24 | |
| Kyle Tucker | OF | ChN | 28 | |
| Alex Verdugo | OF | Atl | 28 | |
| Andrew Abbott | SP | Cin | 25 | |
| Brayan Bello | SP | Bos | 25 | |
| Jacob deGrom | SP | Tex | 36 | |
| Hunter Greene | SP | Cin | 25 | |
| Jack Leiter | SP | Tex | N/A | |
| Tylor Megill | SP | NYN | 29 | |
| Max Meyer | SP | Mia | 26 | |
| Andrew Painter | SP | Phi | N/A | |
| Jose Quintana | SP | Mil | 36 | |
| Chris Sale | SP | Atl | 36 | |
| Roki Sasaki | SP | LAD | 23 | |
| Brady Singer | SP | Cin | 28 | |
| Yoshinobu Yamamoto | SP | LAD | 26 |