| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| William Contreras | C | Mil | 27 | |
| Keibert Ruiz | C | Was | 26 | |
| Ty France | 1B | Min | 30 | |
| Vladimir Guerrero Jr. | 1B | Tor | 26 | |
| Jose Altuve | 2B (OF) | Hou | 34 | |
| Willi Castro | 2B (SS,3B) | Min | 28 | April 24, 2025:10 Day IL |
| Brendan Donovan | 2B (SS,OF) | StL | 28 | |
| Willy Adames | SS | SF | 29 | |
| Javier Baez | SS (3B,OF) | Det | 32 | |
| Xander Bogaerts | SS | SD | 32 | |
| JJ Wetherholt | SS | StL | 22 | |
| Isaac Paredes | 3B | Hou | 26 | |
| Austin Riley | 3B | Atl | 28 | |
| Wilyer Abreu | OF | Bos | 25 | |
| Colton Cowser | OF | Bal | 25 | March 31, 2025:60 Day IL-Left thumb fracture |
| Lourdes Gurriel | OF | Ari | 31 | |
| Austin Hays | OF | Cin | 29 | May 02, 2025:10 Day IL |
| Trevor Larnach | OF | Min | 28 | |
| Brent Rooker | OF | Oak | 30 | |
| Kyle Schwarber | OF | Phi | 32 | |
| Mike Trout | OF | LAA | 33 | May 02, 2025:10 Day IL |
| Taj Bradley | SP | TB | 24 | |
| Bowden Francis | SP | Tor | 29 | |
| Max Fried | SP | NYA | 31 | |
| Zac Gallen | SP | Ari | 29 | |
| Sean Manaea | SP | NYN | 33 | March 27, 2025:60 Day IL |
| Aaron Nola | SP | Phi | 31 | |
| Bailey Ober | SP | Min | 29 | |
| Freddy Peralta | SP | Mil | 28 | |
| Carlos Rodon | SP | NYA | 32 | |
| Eduardo Rodriguez | SP | Ari | 32 | |
| Clarke Schmidt | SP | NYA | 29 | |
| Luke Jackson | RP | Tex | 33 | |
| Andres Munoz | RP | Sea | 26 |