| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Francisco Álvarez | C | NYN | 23 | |
| Miguel Amaya | C | ChN | 26 | |
| Tyler Stephenson | C | Cin | 28 | |
| Colt Keith | 1B (2B) | Det | 23 | |
| Nathaniel Lowe | 1B | Was | 29 | |
| Matt Mervis | 1B | Mia | 27 | |
| Jazz Chisholm Jr. | 2B | NYA | 27 | May 02, 2025:15 Day IL-Oblique |
| Gavin Lux | 2B (OF) | Cin | 27 | |
| Zach McKinstry | 2B (3B,OF) | Det | 30 | |
| Matt McLain | 2B | Cin | 25 | |
| Corey Seager | SS | Tex | 31 | April 23, 2025:10 Day IL |
| Jose Tena | SS (3B) | Was | 24 | |
| Anthony Volpe | SS | NYA | 24 | |
| Jace Jung | 3B | Det | 24 | |
| Jose Ramirez | 3B | Cle | 32 | |
| Tommy Edman | OF (2B) | LAD | 29 | |
| TJ Friedl | OF | Cin | 29 | |
| Bryan Reynolds | OF | Pit | 30 | |
| Luis Robert Jr. | OF | ChA | 27 | |
| Brent Rooker | OF | Oak | 30 | |
| Kyle Tucker | OF | ChN | 28 | |
| Hunter Brown | SP | Hou | 26 | |
| Pat Corbin | SP | Tex | 35 | |
| Shota Imanaga | SP | ChN | 31 | |
| Shane McClanahan | SP | TB | 28 | March 26, 2025:60 Day IL-Ab strain |
| Max Meyer | SP | Mia | 26 | |
| Chris Sale | SP | Atl | 36 | |
| Brady Singer | SP | Cin | 28 | |
| Shane Smith | SP | ChA | N/A | |
| Jeffrey Springs | SP | Oak | 32 | |
| Justin Verlander | SP | SF | 42 | |
| Emmanuel Clase | RP | Cle | 27 | |
| Ryan Pressly | RP | ChN | 36 |