| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Elias Diaz | C | SD | 34 | |
| Keibert Ruiz | C | Was | 26 | |
| Luis Arraez | 1B | SD | 28 | |
| Vladimir Guerrero Jr. | 1B | Tor | 26 | |
| Willi Castro | 2B (SS,3B) | Min | 28 | April 24, 2025:10 Day IL |
| Nico Hoerner | 2B | ChN | 27 | |
| Orlando Arcia | SS | Atl | 30 | |
| Mookie Betts | SS | LAD | 32 | |
| Isiah Kiner-Falefa | SS | Pit | 30 | |
| Zach Neto | SS | LAA | 24 | |
| Ke'Bryan Hayes | 3B | Pit | 28 | |
| Jordan Westburg | 3B (2B) | Bal | 26 | April 28, 2025:10 Day IL |
| Lawrence Butler | OF | Oak | 24 | |
| Kerry Carpenter | OF | Det | 27 | |
| Kameron Misner | OF | TB | N/A | |
| Cedric Mullins II | OF | Bal | 30 | |
| Alex Verdugo | OF | Atl | 28 | |
| Logan Allen | SP | Cle | 26 | |
| Nestor Cortes Jr. | SP | Mil | 30 | April 06, 2025:60 Day IL-Left elbow flexor strain |
| Tony Gonsolin | SP | LAD | 30 | |
| Hunter Greene | SP | Cin | 25 | |
| Bryce Miller | SP | Sea | 26 | |
| Aaron Nola | SP | Phi | 31 | |
| Ryan Pepiot | SP | TB | 27 | |
| Martin Perez | SP | ChA | 34 | April 19, 2025:60 Day IL |
| Brandon Pfaadt | SP | Ari | 26 | |
| Colin Rea | SP (RP) | ChN | 34 | |
| Spencer Schwellenbach | SP | Atl | 24 | |
| Justin Steele | SP | ChN | 29 | April 09, 2025:60 Day IL |
| Framber Valdez | SP | Hou | 31 | |
| Logan Webb | SP | SF | 28 | |
| Anthony Bender | RP | Mia | 30 | |
| Aroldis Chapman | RP | Bos | 37 | |
| Emilio Pagan | RP | Cin | 33 |