| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| William Contreras | C | Mil | 27 | |
| Tyler Stephenson | C | Cin | 28 | |
| Paul Goldschmidt | 1B | NYA | 37 | |
| Ryan Mountcastle | 1B | Bal | 28 | |
| Jose Altuve | 2B (OF) | Hou | 34 | |
| Jake Cronenworth | 2B | SD | 31 | April 11, 2025:10 Day IL |
| Brooks Lee | 2B (3B) | Min | 24 | |
| Carlos Correa | SS | Min | 30 | |
| J.P. Crawford | SS | Sea | 30 | |
| Nolan Arenado | 3B | StL | 34 | |
| Matt Chapman | 3B | SF | 32 | |
| Dylan Moore | 3B (2B,OF) | Sea | 32 | April 29, 2025:10 Day IL |
| Ben Williamson | 3B | Sea | N/A | |
| Andrew Benintendi | OF | ChA | 30 | |
| Nick Castellanos | OF | Phi | 33 | |
| Brandon Nimmo | OF | NYN | 32 | |
| Kyle Schwarber | OF | Phi | 32 | |
| Daulton Varsho | OF | Tor | 28 | |
| Eli White | OF | Atl | 30 | |
| Mike Yastrzemski | OF | SF | 34 | |
| Chris Bassitt | SP | Tor | 36 | |
| Hunter Brown | SP | Hou | 26 | |
| Corbin Burnes | SP | Ari | 30 | |
| Griffin Canning | SP | NYN | 28 | |
| Luis Castillo | SP | Sea | 32 | |
| Nestor Cortes Jr. | SP | Mil | 30 | April 06, 2025:60 Day IL-Left elbow flexor strain |
| Erick Fedde | SP | StL | 32 | |
| Sonny Gray | SP | StL | 35 | |
| Tyler Mahle | SP | Tex | 30 | |
| Aaron Nola | SP | Phi | 31 | |
| Luke Weaver | SP (RP) | NYA | 31 | |
| José Alvarado | RP | Phi | 29 | |
| Jhoan Duran | RP | Min | 27 | |
| Devin Williams | RP | NYA | 30 |