| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Elias Diaz | C | SD | 34 | |
| Ivan Herrera | C | StL | 24 | April 07, 2025:15 Day IL-Knee |
| Tyler Stephenson | C | Cin | 28 | |
| Austin Wynns | C | Cin | 34 | |
| Pete Alonso | 1B | NYN | 30 | |
| Colt Keith | 1B (2B) | Det | 23 | |
| Matt Mervis | 1B | Mia | 27 | |
| Zack Gelof | 2B | Oak | 25 | March 23, 2025:15 Day IL |
| Nolan Gorman | 2B | StL | 24 | |
| Zach McKinstry | 2B (3B,OF) | Det | 30 | |
| Marcus Semien | 2B | Tex | 34 | |
| Oswaldo Cabrera | SS (3B) | NYA | 26 | |
| Ezequiel Tovar | SS | Col | 23 | April 19, 2025:10 Day IL |
| Maikel Garcia | 3B (2B,OF) | KC | 25 | |
| Royce Lewis | 3B | Min | 25 | March 27, 2025:15 Day IL-Ab strain |
| Jorge Polanco | 3B | Sea | 31 | |
| Yordan Alvarez | OF | Hou | 27 | |
| Brenton Doyle | OF | Col | 26 | |
| Austin Hays | OF | Cin | 29 | May 02, 2025:10 Day IL |
| Brandon Nimmo | OF | NYN | 32 | |
| Bryan Reynolds | OF | Pit | 30 | |
| Shane Baz | SP | TB | 25 | |
| Pat Corbin | SP | Tex | 35 | |
| Hunter Dobbins | SP | Bos | N/A | |
| Hunter Greene | SP | Cin | 25 | |
| Nick Lodolo | SP | Cin | 27 | |
| Shane McClanahan | SP | TB | 28 | March 26, 2025:60 Day IL-Ab strain |
| Shane Smith | SP | ChA | N/A | |
| Justin Verlander | SP | SF | 42 | |
| Logan Webb | SP | SF | 28 | |
| Emmanuel Clase | RP | Cle | 27 | |
| Luke Jackson | RP | Tex | 33 | |
| Ryan Pressly | RP | ChN | 36 | |
| Will Vest | RP | Det | 29 |