| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Miguel Amaya | C | ChN | 26 | |
| Agustin Ramirez | C | Mia | 23 | |
| Triston Casas | 1B | Bos | 25 | |
| Tyler Soderstrom | 1B (OF) | Oak | 23 | |
| Kristian Campbell | 2B (OF) | Bos | 22 | |
| Jake Cronenworth | 2B | SD | 31 | April 11, 2025:10 Day IL |
| Luke Keaschall | 2B | Min | 22 | April 26, 2025:10 Day IL |
| Brooks Lee | 2B (3B) | Min | 24 | |
| Matt McLain | 2B | Cin | 25 | |
| Jose Caballero | SS (3B,OF) | TB | 28 | |
| Trevor Story | SS | Bos | 32 | |
| Carson Williams | SS | TB | 21 | |
| Masyn Winn | SS | StL | 23 | |
| Josh Jung | 3B | Tex | 27 | |
| Josh Smith | 3B (SS) | Tex | 27 | |
| Mark Vientos | 3B | NYN | 25 | |
| Wilyer Abreu | OF | Bos | 25 | |
| Lawrence Butler | OF | Oak | 24 | |
| Evan Carter | OF | Tex | 22 | |
| Jackson Merrill | OF | SD | 22 | April 08, 2025:10 Day IL |
| Gavin Sheets | OF (1B) | SD | 29 | |
| Seiya Suzuki | OF | ChN | 30 | |
| Jack Flaherty | SP | Det | 29 | |
| Lucas Giolito | SP | Bos | 30 | |
| Tanner Houck | SP | Bos | 28 | |
| Pablo Lopez | SP | Min | 29 | |
| Lance McCullers | SP | Hou | 31 | March 27, 2025:15 Day IL |
| Andre Pallante | SP | StL | 26 | |
| JP Sears | SP | Oak | 29 | |
| Luis Severino | SP | Oak | 31 | |
| Justin Verlander | SP | SF | 42 | |
| Bryan Woo | SP | Sea | 25 | |
| Pete Fairbanks | RP | TB | 31 | |
| Raisel Iglesias | RP | Atl | 35 |