| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Samuel Basallo | C | Bal | 20 | |
| Shea Langeliers | C | Oak | 27 | |
| J.T. Realmuto | C | Phi | 34 | |
| Jeimer Candelario | 1B (3B) | Cin | 31 | April 30, 2025:10 Day IL |
| Ryan Mountcastle | 1B | Bal | 28 | |
| Luisangel Acuna | 2B | NYN | 23 | |
| Jose Altuve | 2B (OF) | Hou | 34 | |
| Ketel Marte | 2B | Ari | 31 | |
| Zach McKinstry | 2B (3B,OF) | Det | 30 | |
| CJ Abrams | SS | Was | 24 | |
| Jose Caballero | SS (3B,OF) | TB | 28 | |
| Xavier Edwards | SS | Mia | 25 | |
| Jose Ramirez | 3B | Cle | 32 | |
| Alec Burleson | OF (1B) | StL | 26 | |
| Kerry Carpenter | OF | Det | 27 | |
| Colton Cowser | OF | Bal | 25 | March 31, 2025:60 Day IL-Left thumb fracture |
| Jurickson Profar | OF | Atl | 32 | |
| Bryan Reynolds | OF | Pit | 30 | |
| Spencer Steer | OF (1B) | Cin | 27 | |
| Matt Wallner | OF | Min | 27 | April 17, 2025:10 Day IL |
| Spencer Arrighetti | SP | Hou | N/A | April 08, 2025:15 Day IL |
| Luis Castillo | SP | Sea | 32 | |
| Nestor Cortes Jr. | SP | Mil | 30 | April 06, 2025:60 Day IL-Left elbow flexor strain |
| Bowden Francis | SP | Tor | 29 | |
| Sonny Gray | SP | StL | 35 | |
| Hunter Greene | SP | Cin | 25 | |
| Shota Imanaga | SP | ChN | 31 | |
| Yusei Kikuchi | SP | LAA | 33 | |
| Michael King | SP | SD | 29 | |
| George Kirby | SP | Sea | 27 | March 27, 2025:15 Day IL |
| Jeffrey Springs | SP | Oak | 32 | |
| Spencer Strider | SP | Atl | 26 | April 21, 2025:15 Day IL |
| Framber Valdez | SP | Hou | 31 | |
| Randy Vasquez | SP | SD | 26 |