| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Austin Wells | C | NYA | 26 | |
| Nick Kurtz | 1B | Oak | 22 | |
| Kyle Manzardo | 1B | Cle | 25 | |
| Jackson Holliday | 2B (SS) | Bal | 21 | |
| Jordan Lawlar | SS (2B,3B) | Ari | 23 | |
| Ronny Mauricio | SS (2B,3B) | NYN | 24 | |
| Sebastian Walcott | SS | Tex | 19 | |
| Jett Williams | SS | NYN | 22 | |
| Jacob Wilson | SS | Oak | 23 | |
| Jordan Westburg | 3B (2B) | Bal | 26 | |
| Jackson Chourio | OF | Mil | 21 | |
| Wyatt Langford | OF | Tex | 23 | September 24, 2025:10 Day IL |
| Lazaro Montes | OF | Sea | 21 | |
| Andy Pages | OF | LAD | 24 | |
| Julio Rodriguez | OF | Sea | 24 | |
| Brent Rooker | OF | Oak | 31 | |
| Colby Thomas | OF | Oak | 24 | |
| Jose Berrios | SP | Tor | 31 | September 25, 2025:15 Day IL |
| Bubba Chandler | SP (RP) | Pit | N/A | |
| Zach Eflin | SP | Bal | 31 | July 31, 2025:60 Day IL |
| Zac Gallen | SP | Ari | 30 | |
| Clay Holmes | SP | NYN | 32 | |
| Grant Holmes | SP | Atl | N/A | July 27, 2025:60 Day IL |
| George Kirby | SP | Sea | 27 | |
| David Peterson | SP | NYN | 30 | |
| Brandon Pfaadt | SP | Ari | 27 | |
| Carlos Rodon | SP | NYA | 32 | |
| Kodai Senga | SP | NYN | 32 | |
| Emmet Sheehan | SP (RP) | LAD | 25 | |
| Aroldis Chapman | RP | Bos | 37 | |
| Daniel Palencia | RP | ChN | N/A | |
| Devin Williams | RP | NYA | 31 |