| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Logan O'Hoppe | C | LAA | 25 | |
| Austin Wells | C | NYA | 25 | |
| Kyle Manzardo | 1B | Cle | 24 | |
| Andrew Vaughn | 1B | ChA | 27 | |
| Ozzie Albies | 2B | Atl | 28 | |
| Jackson Holliday | 2B (SS) | Bal | 21 | |
| Christian Moore | 2B | LAA | 22 | |
| Jordan Lawlar | SS | Ari | 22 | |
| Corey Seager | SS | Tex | 31 | April 23, 2025:10 Day IL |
| Sebastian Walcott | SS | Tex | 19 | |
| Jacob Wilson | SS | Oak | 23 | |
| Jordan Westburg | 3B (2B) | Bal | 26 | April 28, 2025:10 Day IL |
| Jackson Chourio | OF | Mil | 21 | |
| Michael Conforto | OF | LAD | 32 | |
| Wyatt Langford | OF | Tex | 23 | |
| Julio Rodriguez | OF | Sea | 24 | |
| Brent Rooker | OF | Oak | 30 | |
| Jordan Walker | OF | StL | 22 | |
| Walker Buehler | SP | Bos | 30 | May 02, 2025:15 Day IL-Shoulder |
| Bubba Chandler | SP | Pit | N/A | |
| Zac Gallen | SP | Ari | 29 | |
| Clay Holmes | SP | NYN | 32 | |
| Jackson Jobe | SP | Det | 22 | |
| Jared Jones | SP | Pit | 23 | March 27, 2025:60 Day IL |
| Clayton Kershaw | SP | LAD | 37 | March 27, 2025:15 Day IL-Ab strain |
| Lance McCullers | SP | Hou | 31 | March 27, 2025:15 Day IL |
| David Peterson | SP | NYN | 29 | |
| Carlos Rodon | SP | NYA | 32 | |
| Luis Severino | SP | Oak | 31 | |
| Tarik Skubal | SP | Det | 28 | |
| Tomoyuki Sugano | SP | Bal | 35 | |
| Luke Weaver | SP (RP) | NYA | 31 | |
| Gavin Williams | SP | Cle | 25 | |
| Aroldis Chapman | RP | Bos | 37 |