| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Adley Rutschman | C | Bal | 27 | |
| Jonathan Aranda | 1B | TB | 26 | |
| Jeimer Candelario | 1B (3B) | Cin | 31 | April 30, 2025:10 Day IL |
| Yandy Diaz | 1B | TB | 33 | |
| Christian Encarnacion-Strand | 1B | Cin | 25 | April 17, 2025:10 Day IL |
| Travis Bazzana | 2B | Cle | 22 | |
| Jake Cronenworth | 2B | SD | 31 | April 11, 2025:10 Day IL |
| Nolan Gorman | 2B | StL | 24 | |
| Xander Bogaerts | SS | SD | 32 | |
| Ha-seong Kim | SS | TB | 29 | March 27, 2025:10 Day IL |
| Maikel Garcia | 3B (2B,OF) | KC | 25 | |
| Manny Machado | 3B | SD | 32 | |
| Harrison Bader | OF | Min | 30 | |
| Alec Burleson | OF (1B) | StL | 26 | |
| Kerry Carpenter | OF | Det | 27 | |
| Jarren Duran | OF | Bos | 28 | |
| Lourdes Gurriel | OF | Ari | 31 | |
| Aaron Judge | OF | NYA | 33 | |
| Trevor Larnach | OF | Min | 28 | |
| Andy Pages | OF | LAD | 24 | |
| Jesus Sanchez | OF | Mia | 27 | |
| Cody Bradford | SP | Tex | 27 | |
| Hunter Brown | SP | Hou | 26 | |
| Jack Flaherty | SP | Det | 29 | |
| Zac Gallen | SP | Ari | 29 | |
| Jared Jones | SP | Pit | 23 | March 27, 2025:60 Day IL |
| Yusei Kikuchi | SP | LAA | 33 | |
| Nick Lodolo | SP | Cin | 27 | |
| Cristopher Sanchez | SP | Phi | 28 | |
| Max Scherzer | SP | Tor | 40 | March 30, 2025:15 Day IL-Thumb |
| Blake Snell | SP | LAD | 32 | April 06, 2025:15 Day IL-Ab strain |
| Pete Fairbanks | RP | TB | 31 | |
| Jason Foley | RP | Det | 29 | |
| Griffin Jax | RP | Min | 30 |